GPRASP2 and CHRM1

Number of citations of the paper that reports this interaction (PubMedID 15086532)
0

Data Source:
HPRD (in vitro)

		GPRASP2	CHRM1
Description		G protein-coupled receptor associated sorting protein 2	cholinergic receptor muscarinic 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Membrane Dendrite Asymmetric Synapse Presynaptic Membrane Axon Terminus Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Cholinergic Synapse
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Hematopoietic Stem Cell Homeostasis	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Nervous System Development Regulation Of Locomotion Positive Regulation Of Monoatomic Ion Transport Saliva Secretion Cognition Regulation Of Postsynaptic Membrane Potential Regulation Of Glial Cell Proliferation Positive Regulation Of Intracellular Protein Transport Acetylcholine Receptor Signaling Pathway Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways			Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs			Cevimeline Tramadol Trospium Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Promazine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Amoxapine Cinnarizine Atropine Nicardipine Pirenzepine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupentixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Ketamine Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Staurosporine Acetylcholine Arecoline Mepenzolate NGX267 ALKS 27 Norclozapine Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Pyrantel Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS			Urate levels ( 31578528)
Interacting Genes		52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 DSCR9 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688	5 interacting genes: CDC14A GNAI2 GPRASP1 GPRASP2 RGS7
Entrez ID		114928	1128
HPRD ID		06612	00338
Ensembl ID		ENSG00000158301	ENSG00000168539
Uniprot IDs		B3KW05 Q96D09	P11229 Q53XZ3
PDB IDs			5CXV 6OIJ 6WJC 6ZFZ 6ZG4 6ZG9
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Trans-synaptic Signaling G Protein-coupled Acetylcholine Receptor Activity Synaptic Signaling Neuromuscular Synaptic Transmission Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Export From Nucleus Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Microtubule Cytoskeleton Organization Cholinergic Synapse Dendrite	Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein-coupled Receptor Catabolic Process Kinociliary Basal Body Negative Regulation Of Signal Transduction Purinergic Nucleotide Receptor Signaling Pathway Guanyl Nucleotide Binding Regulation Of Urine Volume Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Negative Regulation Of Cell Communication Cell Division G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cytosol Cell Tip Dendrite Terminus G-protein Beta-subunit Binding Kinocilium Stereocilium Tip Regulation Of Exit From Mitosis Receptor Catabolic Process Dendrite Gamma-aminobutyric Acid Signaling Pathway Regulation Of Superoxide Metabolic Process G-protein Alpha-subunit Binding Hematopoietic Stem Cell Homeostasis
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