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GPRASP2 and ADRB1
Number of citations of the paper that reports this interaction (PMID
15086532
)
18
Data Source:
HPRD
(in vitro)
GPRASP2
ADRB1
Gene Name
G protein-coupled receptor associated sorting protein 2
adrenoceptor beta 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Nucleus
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Molecular Function
Beta-amyloid Binding
Beta-adrenergic Receptor Activity
Beta1-adrenergic Receptor Activity
Receptor Signaling Protein Activity
Ras Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Drug Binding
PDZ Domain Binding
Alpha-2A Adrenergic Receptor Binding
Dopamine Binding
Protein Heterodimerization Activity
Epinephrine Binding
Norepinephrine Binding
Biological Process
Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
Diet Induced Thermogenesis
Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure
Positive Regulation Of The Force Of Heart Contraction By Norepinephrine
Positive Regulation Of Systemic Arterial Blood Pressure
Glycogen Catabolic Process
Apoptotic Process
Activation Of Adenylate Cyclase Activity
Rho Protein Signal Transduction
Aging
Memory
Response To Cold
Sensory Perception Of Pain
Positive Regulation Of CAMP Biosynthetic Process
Heat Generation
Positive Regulation Of Ras GTPase Activity
Protein Localization To Organelle
Negative Regulation Of Urine Volume
Negative Regulation Of Multicellular Organism Growth
Wound Healing
Fear Response
Positive Regulation Of Apoptotic Process
Positive Regulation Of CAMP-mediated Signaling
Negative Regulation Of Smooth Muscle Contraction
Positive Regulation Of Saliva Secretion
Brown Fat Cell Differentiation
Regulation Of Calcium Ion Transport
Lipid Homeostasis
Regulation Of Inhibitory Postsynaptic Membrane Potential
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Regulation Of Cardiac Muscle Cell Contraction
Positive Regulation Of Renin Secretion Into Blood Stream
Positive Regulation Of Cation Channel Activity
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
G alpha (s) signalling events
Adrenoceptors
Class A/1 (Rhodopsin-like receptors)
Amine ligand-binding receptors
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Drugs
Esmolol
Betaxolol
Isoetharine
Metoprolol
Atenolol
Norepinephrine
Timolol
Phenylpropanolamine
Sotalol
Carteolol
Propranolol
Labetalol
Bisoprolol
Epinephrine
Dobutamine
Pseudoephedrine
Alprenolol
Pindolol
Salbutamol
Isoproterenol
Arbutamine
Amiodarone
Carvedilol
Desipramine
Acebutolol
Nadolol
Levobunolol
Metipranolol
Fenoterol
Pirbuterol
Bevantolol
Practolol
Penbutolol
Ephedra
Clenbuterol
Oxprenolol
Dronedarone
Nebivolol
Asenapine
Droxidopa
4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Bopindolol
Bupranolol
Diseases
GWAS
Birth weight (
23202124
)
Blood pressure (
21909110
)
Gaucher disease severity (
22388998
)
Protein-Protein Interactions
25 interactors:
ADRB1
ARHGEF6
BARD1
BZRAP1
C6orf165
CALCR
CBX8
CHRM1
CHRM2
DISC1
FRAT1
HAP1
HRH2
HTR7
HTT
KIAA1377
LOC149950
LRIF1
MYOT
PTN
RPS6KA5
STMN2
TCF25
TXN
TXN2
16 interactors:
ADRA2A
ARRB1
DLG1
DLG4
DLGAP2
GIPC1
GOPC
GPRASP1
GPRASP2
GRB2
MAGI2
MAGI3
NOS1
SH3GL2
SH3GL3
SNTA1
Entrez ID
114928
153
HPRD ID
06612
00181
Ensembl ID
ENSG00000158301
ENSG00000043591
Uniprot IDs
B3KW05
Q96D09
P08588
PDB IDs
2LSQ
Enriched GO Terms of Interacting Partners
?
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Cell Surface Receptor Signaling Pathway
Cell-cell Signaling
Homeostatic Process
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cation Channel Activity
Cell Communication
Cellular Response To Stimulus
Cognition
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Synaptic Transmission
Positive Regulation Of Ion Transmembrane Transporter Activity
Negative Regulation Of Protein Export From Nucleus
Positive Regulation Of Transporter Activity
Signaling
Positive Regulation Of Ion Transport
Cellular Homeostasis
Regulation Of Blood Vessel Size
Regulation Of Tube Size
Positive Regulation Of Ion Transmembrane Transport
Regulation Of Cation Channel Activity
Signal Transduction
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Learning Or Memory
Response To Stimulus
Glycerol Ether Metabolic Process
Cell Redox Homeostasis
Memory
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Cellular Process
Positive Regulation Of Calcium Ion Transmembrane Transporter Activity
Secretion
Learning
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Regulation Of Protein Export From Nucleus
Vasoconstriction
Developmental Process
Vesicle Transport Along Microtubule
Positive Regulation Of Adenylate Cyclase Activity
Anatomical Structure Development
Regulation Of Intracellular Transport
Positive Regulation Of Receptor Activity
Regulation Of Calcium Ion Transport
Single-organism Behavior
Response To Reactive Oxygen Species
Nervous System Development
Positive Regulation Of Signal Transduction
Regulation Of Receptor Internalization
Regulation Of Signal Transduction
Regulation Of Vesicle-mediated Transport
Negative Regulation Of Signal Transduction
Regulation Of Signaling
Negative Regulation Of Signaling
Post-Golgi Vesicle-mediated Transport
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Negative Regulation Of Adrenergic Receptor Signaling Pathway
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Receptor Clustering
Regulation Of Ion Transmembrane Transport
Regulation Of Endocytosis
Regulation Of Adrenergic Receptor Signaling Pathway
Nucleotide Phosphorylation
Signaling
Regulation Of Cellular Component Organization
Regulation Of Potassium Ion Transport
Cell Communication
Receptor Localization To Synapse
Regulation Of Sodium Ion Transport
Cell-cell Signaling
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Movement Of Cell Or Subcellular Component
Intracellular Transport
Regulation Of ERBB Signaling Pathway
Positive Regulation Of Catalytic Activity
Receptor Metabolic Process
Golgi Vesicle Transport
Synaptic Transmission
Regulation Of Ion Transport
Regulation Of Catalytic Activity
Cellular Localization
Endocytosis
Regulation Of Intracellular Signal Transduction
Protein Localization To Synapse
Positive Regulation Of Transport
Positive Regulation Of Receptor Internalization
Locomotion
Positive Regulation Of Signal Transduction
Axon Guidance
Positive Regulation Of Histone Acetylation
Negative Regulation Of Transport
Regulation Of Cellular Amino Acid Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Ion Transmembrane Transporter Activity
Positive Regulation Of Organelle Organization
Regulation Of Transmembrane Transporter Activity
Tagcloud
?
alpha5
appl1
assembles
cargoes
deafness
dimerizing
drd2
factorbeta
gh1
gh2
gipc
gipc1
gipc2
gipc3
gipcs
gpcrs
hbc
lrp1
myo6
nonsyndromic
nrp1
ntrk1
pdz
rgs19
rtks
sdc4
sema4c
tgfbetar3
vangl2
Tagcloud (Difference)
?
alpha5
appl1
assembles
cargoes
deafness
dimerizing
drd2
factorbeta
gh1
gh2
gipc
gipc1
gipc2
gipc3
gipcs
gpcrs
hbc
lrp1
myo6
nonsyndromic
nrp1
ntrk1
pdz
rgs19
rtks
sdc4
sema4c
tgfbetar3
vangl2
Tagcloud (Intersection)
?