GPRASP2 and SEZ6L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPRASP2	SEZ6L
Description		G protein-coupled receptor associated sorting protein 2	seizure related 6 homolog like
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuronal Cell Body
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding	Protein Binding
	Biological Process	Hematopoietic Stem Cell Homeostasis	Adult Locomotory Behavior Cerebellar Purkinje Cell Layer Development Synapse Maturation
Pathways
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378) Copper levels ( 26025379) Insulin resistance/response ( 21901158) Vascular brain injury ( 25188341)
Interacting Genes		52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 DSCR9 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688	5 interacting genes: APP GPRASP2 RSPH1 UBQLN1 UBQLN2
Entrez ID		114928	23544
HPRD ID		06612	08449
Ensembl ID		ENSG00000158301	ENSG00000100095
Uniprot IDs		B3KW05 Q96D09	B7ZLJ8 Q9BYH1
PDB IDs			2YRA
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Trans-synaptic Signaling G Protein-coupled Acetylcholine Receptor Activity Synaptic Signaling Neuromuscular Synaptic Transmission Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Export From Nucleus Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Microtubule Cytoskeleton Organization Cholinergic Synapse Dendrite	Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteolysis Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Cellular Response To Stress Regulation Of Receptor Internalization Autophagosome Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Catabolic Process Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Radial Spoke Head 1 Radial Spoke Head 3 Positive Regulation Of Protein Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Cytoplasmic Vesicle
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