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ITCH and URI1
Number of citations of the paper that reports this interaction (PMID
16055720
)
52
Data Source:
BioGRID
(pull down)
ITCH
URI1
Gene Name
itchy E3 ubiquitin protein ligase
URI1, prefoldin-like chaperone
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Cytoplasmic Vesicle
Extracellular Vesicular Exosome
Nucleus
DNA-directed RNA Polymerase II, Core Complex
Cytoplasm
Mitochondrion
Dendrite
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Ribonucleoprotein Complex Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Transcription Corepressor Activity
Chromatin Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Phosphatase Inhibitor Activity
Biological Process
Regulation Of Cell Growth
Positive Regulation Of T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Inflammatory Response
Notch Signaling Pathway
Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Negative Regulation Of Alpha-beta T Cell Proliferation
Viral Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Growth
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Response To Virus
Negative Regulation Of Phosphatase Activity
Cellular Response To Growth Factor Stimulus
Cellular Response To Steroid Hormone Stimulus
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Hedgehog 'off' state
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOD1/2 Signaling Pathway
Signaling by NOTCH1
Hedgehog 'on' state
Signaling by NOTCH1 in Cancer
Class I MHC mediated antigen processing & presentation
FBXW7 Mutants and NOTCH1 in Cancer
Innate Immune System
Downregulation of ERBB4 signaling
Signaling by NOTCH
Signaling by ERBB4
Activated NOTCH1 Transmits Signal to the Nucleus
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
80 interactors:
ARID1A
ARRB2
ARRDC1
ARRDC3
ATN1
BECN1
CBL
CBLC
CDC34
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
DVL2
ERBB4
EWSR1
FYN
GNAI2
HNRNPL
HNRNPUL1
JUN
LAPTM5
LATS1
LITAF
MAP2K4
MAPK8
MLANA
N4BP1
NDFIP2
NEDD9
NFE2
NOTCH1
NUDT21
NUMB
PABPC1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SNX9
SPG20
STAM2
TP73
TRPC4
TRPV1
TRPV4
TXNIP
UBAP2
UBAP2L
UBC
UBE2D2
UBE2D3
UBE2E1
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
URI1
WBP2
9 interactors:
APP
ATF7
DMAP1
GTF2F2
ITCH
NEDD4
POLR2E
RPS6KB1
STAP1
Entrez ID
83737
8725
HPRD ID
07565
11943
Ensembl ID
ENSG00000078747
ENSG00000105176
Uniprot IDs
Q96J02
O94763
PDB IDs
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Response To Stimulus
RNA Metabolic Process
Gene Expression
Transcription From RNA Polymerase II Promoter
Response To Growth Factor
Positive Regulation Of Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Positive Regulation Of Signal Transduction
Protein Ubiquitination
Response To Organic Substance
Cellular Response To Organic Substance
Protein K48-linked Ubiquitination
Positive Regulation Of Cellular Biosynthetic Process
Protein Modification By Small Protein Conjugation
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Protein Polyubiquitination
Regulation Of Signaling
Macromolecule Biosynthetic Process
Regulation Of Protein Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Nucleobase-containing Compound Metabolic Process
Nucleosome Disassembly
TRIF-dependent Toll-like Receptor Signaling Pathway
Programmed Cell Death
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Protein Catabolic Process
Regulation Of Cellular Component Organization
DNA-templated Transcription, Initiation
Cell Death
Death
MRNA Splicing, Via Spliceosome
Viral Process
Regulation Of Gene Expression
Intracellular Receptor Signaling Pathway
Regulation Of Growth
7-methylguanosine MRNA Capping
Protein K63-linked Ubiquitination
7-methylguanosine RNA Capping
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Viral Transcription
Neuromuscular Junction Development
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Transmission Of Virus
Development Involved In Symbiotic Interaction
Regulation Of Nitrogen Compound Metabolic Process
MRNA Processing
DNA-templated Transcription, Elongation
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Response To Stress
Regulation Of Synapse Structure Or Activity
Regulation Of Metabolic Process
Interaction With Host
Regulation Of Type I Interferon Production
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Nucleocytoplasmic Transport
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Skeletal Muscle Tissue Growth
Locomotion
Positive Regulation Of Mitotic Cell Cycle
MRNA Metabolic Process
Immune Response
Negative Regulation Of Gene Expression
RNA Processing
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Collateral Sprouting In Absence Of Injury
Notch Signaling Pathway
Regulation Of Viral Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Protein Polyubiquitination
Skeletal Muscle Atrophy
Tagcloud
?
ascertain
benzoin
biweekly
break
clearance
clinic
convenience
eradicating
erosions
ethanol
individual
irritation
ns
paint
pb
pe
penile
penis
podophyllin
regimens
resin
sequentially
superficial
supervised
tincture
treated
wart
warts
week
Tagcloud (Difference)
?
ascertain
benzoin
biweekly
break
clearance
clinic
convenience
eradicating
erosions
ethanol
individual
irritation
ns
paint
pb
pe
penile
penis
podophyllin
regimens
resin
sequentially
superficial
supervised
tincture
treated
wart
warts
week
Tagcloud (Intersection)
?