ITCH and UBE2K

Number of citations of the paper that reports this interaction (PubMedID 30017913)
69

Data Source:
BioGRID (pull down)

		ITCH	UBE2K
Description		itchy E3 ubiquitin protein ligase	ubiquitin conjugating enzyme E2 K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Extracellular Exosome Cell Periphery	Nucleus Cytoplasm Cytosol Filopodium Tip
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ribonucleoprotein Complex Binding Ubiquitin-like Protein Ligase Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity Arrestin Family Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Regulation Of Cell Growth Immune System Process Positive Regulation Of T Cell Anergy Negative Regulation Of Immune System Process Positive Regulation Of Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Inflammatory Response Response To Oxidative Stress Positive Regulation Of Catabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Protein Catabolic Process Receptor Internalization Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination CD4-positive, Alpha-beta T Cell Proliferation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Symbiont Entry Into Host Cell Negative Regulation Of Defense Response To Virus Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Protein Autoubiquitination Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination Protein Branched Polyubiquitination Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Receptor Catabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Downregulation of ERBB4 signaling NOD1/2 Signaling Pathway Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Degradation of GLI1 by the proteasome Hedgehog 'on' state Regulation of necroptotic cell death RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31015462 31152163) Fish- and plant-related diet ( 32066663) Heel bone mineral density ( 28869591) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Vitiligo ( 27723757)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)
Interacting Genes		132 interacting genes: AGO2 AKT1 ARHGEF7 ARID1A ARRB2 ARRDC3 ATN1 BECN1 BIN1 BRAF CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DSCR9 DTX1 DTX3L ERBB4 ESS2 EWSR1 FYN GJA1 GLIS3 GNAI2 H1-2 HNRNPUL1 JUN JUNB KIAA1210 KPNB1 KSR1 LAPTM5 LITAF LRRK1 MAP2 MAP2K1 MAP2K4 MAP3K2 MAPK8 MLANA MLKL MYCT1 N4BP1 NDFIP1 NDFIP2 NEDD9 NFE2 NOTCH1 NRAS NUDT21 NUMB PABPC1 PACSIN1 PIP4P2 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA PRRG4 RAF1 RBM14 REPS2 RHBDD1 RIPK1 RNF11 RORA RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL1 SH3GL2 SIK1 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SMN1 SNX9 SPART SPEN STAM2 STRIP2 SUFU TAB1 TAF15 TGFB1I1 TMEM51 TP73 TRERF1 TRPC4 TRPV1 TRPV4 TTYH3 UBAP2 UBAP2L UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2O UBE2Q1 UBE2Q2 UBE2R2 URI1 UVRAG WASL WBP2 YWHAQ YY1 ZC3H14	98 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 CEBPA DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF213 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM13 TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM6 TRIM63 TSN UBA1 UBA5 UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384
Entrez ID		83737	3093
HPRD ID		07565	04165
Ensembl ID		ENSG00000078747	ENSG00000078140
Uniprot IDs		Q96J02	B3KSH4 B4DIZ2 P61086
PDB IDs		2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 5C7M 5CQ2 5DWS 5DZD 5SXP	1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7 7MYF 7MYH 7OJX
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Nucleus Cytosol Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nucleotide Binding WW Domain Binding Regulation Of Primary Metabolic Process Protein Binding Intracellular Signal Transduction Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Cytoplasm Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Ubiquitination Negative Regulation Of Metabolic Process	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Modification Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Transferase Activity Zinc Ion Binding Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Catabolic Process Proteolysis Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Regulation Of Signaling Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stress Identical Protein Binding Protein K6-linked Ubiquitination Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Innate Immune Response Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction SUMO Transferase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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