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ITCH and CPSF7
Number of citations of the paper that reports this interaction (PMID
16055720
)
52
Data Source:
BioGRID
(pull down)
ITCH
CPSF7
Gene Name
itchy E3 ubiquitin protein ligase
cleavage and polyadenylation specific factor 7, 59kDa
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Cytoplasmic Vesicle
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
MRNA Cleavage Factor Complex
Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Ribonucleoprotein Complex Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
Protein Binding
Poly(A) RNA Binding
Biological Process
Regulation Of Cell Growth
Positive Regulation Of T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Inflammatory Response
Notch Signaling Pathway
Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Negative Regulation Of Alpha-beta T Cell Proliferation
Viral Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
MRNA Splicing, Via Spliceosome
Transcription From RNA Polymerase II Promoter
Termination Of RNA Polymerase II Transcription
RNA Splicing
Gene Expression
MRNA 3'-end Processing
Protein Tetramerization
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Hedgehog 'off' state
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOD1/2 Signaling Pathway
Signaling by NOTCH1
Hedgehog 'on' state
Signaling by NOTCH1 in Cancer
Class I MHC mediated antigen processing & presentation
FBXW7 Mutants and NOTCH1 in Cancer
Innate Immune System
Downregulation of ERBB4 signaling
Signaling by NOTCH
Signaling by ERBB4
Activated NOTCH1 Transmits Signal to the Nucleus
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
Adaptive Immune System
mRNA Splicing
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
Processing of Capped Intronless Pre-mRNA
mRNA Splicing - Major Pathway
Cleavage of Growing Transcript in the Termination Region
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions
80 interactors:
ARID1A
ARRB2
ARRDC1
ARRDC3
ATN1
BECN1
CBL
CBLC
CDC34
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
DVL2
ERBB4
EWSR1
FYN
GNAI2
HNRNPL
HNRNPUL1
JUN
LAPTM5
LATS1
LITAF
MAP2K4
MAPK8
MLANA
N4BP1
NDFIP2
NEDD9
NFE2
NOTCH1
NUDT21
NUMB
PABPC1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SNX9
SPG20
STAM2
TP73
TRPC4
TRPV1
TRPV4
TXNIP
UBAP2
UBAP2L
UBC
UBE2D2
UBE2D3
UBE2E1
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
URI1
WBP2
22 interactors:
AES
APBB1
ARMC7
ATXN1
CLK2
CSNK2A1
DVL2
EPM2AIP1
EWSR1
GCC1
ITCH
NCK2
NUDT21
PRMT2
RUNX1T1
SEC23B
SMAD3
SNRNP25
SORBS3
U2AF2
WBP4
WWOX
Entrez ID
83737
79869
HPRD ID
07565
16906
Ensembl ID
ENSG00000078747
ENSG00000149532
Uniprot IDs
Q96J02
B4DGF8
Q8N684
PDB IDs
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
3N9U
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Response To Stimulus
RNA Metabolic Process
Gene Expression
Transcription From RNA Polymerase II Promoter
Response To Growth Factor
Positive Regulation Of Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Positive Regulation Of Signal Transduction
Protein Ubiquitination
Response To Organic Substance
Cellular Response To Organic Substance
Protein K48-linked Ubiquitination
Positive Regulation Of Cellular Biosynthetic Process
Protein Modification By Small Protein Conjugation
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Protein Polyubiquitination
Regulation Of Signaling
Macromolecule Biosynthetic Process
Regulation Of Protein Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Nucleobase-containing Compound Metabolic Process
Nucleosome Disassembly
TRIF-dependent Toll-like Receptor Signaling Pathway
Programmed Cell Death
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Protein Catabolic Process
Regulation Of Cellular Component Organization
DNA-templated Transcription, Initiation
Cell Death
Death
MRNA Splicing, Via Spliceosome
Regulation Of RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Metabolic Process
Gene Expression
RNA Processing
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Signal Transduction
Negative Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Wnt Signaling Pathway
Regulation Of Signaling
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Growth
Positive Regulation Of Cell Death
Regulation Of Apoptotic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Cell Growth
RNA Splicing
Regulation Of Cell Death
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Signal Transduction
Negative Regulation Of Nucleic Acid-templated Transcription
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Phosphorylation
Negative Regulation Of Signaling
Cellular Macromolecule Biosynthetic Process
MRNA Processing
Macromolecule Biosynthetic Process
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Cycle
Termination Of RNA Polymerase II Transcription
Tagcloud
?
ascertain
benzoin
biweekly
break
clearance
clinic
convenience
eradicating
erosions
ethanol
individual
irritation
ns
paint
pb
pe
penile
penis
podophyllin
regimens
resin
sequentially
superficial
supervised
tincture
treated
wart
warts
week
Tagcloud (Difference)
?
ascertain
benzoin
biweekly
break
clearance
clinic
convenience
eradicating
erosions
ethanol
individual
irritation
ns
paint
pb
pe
penile
penis
podophyllin
regimens
resin
sequentially
superficial
supervised
tincture
treated
wart
warts
week
Tagcloud (Intersection)
?