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ITCH and NUDT21
Number of citations of the paper that reports this interaction (PMID
16055720
)
52
Data Source:
BioGRID
(pull down)
ITCH
NUDT21
Gene Name
itchy E3 ubiquitin protein ligase
nudix (nucleoside diphosphate linked moiety X)-type motif 21
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Cytoplasmic Vesicle
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Centrosome
MRNA Cleavage Factor Complex
Paraspeckles
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Ribonucleoprotein Complex Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
RNA Binding
MRNA Binding
Protein Binding
Hydrolase Activity
AU-rich Element Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Poly(A) RNA Binding
Biological Process
Regulation Of Cell Growth
Positive Regulation Of T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Inflammatory Response
Notch Signaling Pathway
Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Negative Regulation Of Alpha-beta T Cell Proliferation
Viral Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
MRNA Splicing, Via Spliceosome
Transcription From RNA Polymerase II Promoter
Termination Of RNA Polymerase II Transcription
MRNA Polyadenylation
MRNA Processing
RNA Splicing
Gene Expression
MRNA 3'-end Processing
Protein Tetramerization
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Hedgehog 'off' state
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOD1/2 Signaling Pathway
Signaling by NOTCH1
Hedgehog 'on' state
Signaling by NOTCH1 in Cancer
Class I MHC mediated antigen processing & presentation
FBXW7 Mutants and NOTCH1 in Cancer
Innate Immune System
Downregulation of ERBB4 signaling
Signaling by NOTCH
Signaling by ERBB4
Activated NOTCH1 Transmits Signal to the Nucleus
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by Hedgehog
Degradation of GLI1 by the proteasome
Adaptive Immune System
mRNA Splicing
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
Processing of Capped Intronless Pre-mRNA
mRNA Splicing - Major Pathway
Cleavage of Growing Transcript in the Termination Region
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions
80 interactors:
ARID1A
ARRB2
ARRDC1
ARRDC3
ATN1
BECN1
CBL
CBLC
CDC34
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
DVL2
ERBB4
EWSR1
FYN
GNAI2
HNRNPL
HNRNPUL1
JUN
LAPTM5
LATS1
LITAF
MAP2K4
MAPK8
MLANA
N4BP1
NDFIP2
NEDD9
NFE2
NOTCH1
NUDT21
NUMB
PABPC1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SNX9
SPG20
STAM2
TP73
TRPC4
TRPV1
TRPV4
TXNIP
UBAP2
UBAP2L
UBC
UBE2D2
UBE2D3
UBE2E1
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
URI1
WBP2
51 interactors:
A2M
ATXN1
CARM1
CLP1
CPSF6
CPSF7
CTNND2
DBN1
DNMT3L
DYNC1I1
EED
EEF1G
EXOSC6
F13A1
FBN3
FLAD1
FUNDC2
GOLGA2
HSF4
IKZF1
ITCH
JMJD1C
KIAA1377
KIFAP3
MASP1
MYL6
NEDD4
NGEF
NIF3L1
POLR2C
PSMF1
PTN
PYCR1
RBM48
RCC1
RNF19A
RPLP1
SEMA5B
SF3B1
SHC1
SHFM1
SLC44A1
SNCAIP
SNRNP70
SRPK1
TCERG1
TLE1
TRA2A
TRIM27
WWOX
ZBTB48
Entrez ID
83737
11051
HPRD ID
07565
05400
Ensembl ID
ENSG00000078747
ENSG00000167005
Uniprot IDs
Q96J02
O43809
PDB IDs
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
2CL3
2J8Q
3BAP
3BHO
3MDG
3MDI
3N9U
3P5T
3P6Y
3Q2S
3Q2T
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Response To Stimulus
RNA Metabolic Process
Gene Expression
Transcription From RNA Polymerase II Promoter
Response To Growth Factor
Positive Regulation Of Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Regulation Of RNA Metabolic Process
Positive Regulation Of Signal Transduction
Protein Ubiquitination
Response To Organic Substance
Cellular Response To Organic Substance
Protein K48-linked Ubiquitination
Positive Regulation Of Cellular Biosynthetic Process
Protein Modification By Small Protein Conjugation
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Protein Polyubiquitination
Regulation Of Signaling
Macromolecule Biosynthetic Process
Regulation Of Protein Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Nucleobase-containing Compound Metabolic Process
Nucleosome Disassembly
TRIF-dependent Toll-like Receptor Signaling Pathway
Programmed Cell Death
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Cellular Protein Catabolic Process
Regulation Of Cellular Component Organization
DNA-templated Transcription, Initiation
Cell Death
Death
MRNA Splicing, Via Spliceosome
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
MRNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Processing
MRNA Processing
RNA Splicing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Cellular Process
Cellular Metabolic Process
Viral Process
Protein K63-linked Ubiquitination
RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Protein Polyubiquitination
Negative Regulation Of Complement Activation
MRNA 3'-end Processing
Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Gene Expression, Epigenetic
Immune System Process
Developmental Process
RNA 3'-end Processing
Cellular Macromolecule Biosynthetic Process
Regulation Of Dendrite Development
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression By Genetic Imprinting
Blood Coagulation
Macromolecule Biosynthetic Process
Hemostasis
Protein Oligomerization
MRNA Polyadenylation
Anatomical Structure Development
Tagcloud
?
ascertain
benzoin
biweekly
break
clearance
clinic
convenience
eradicating
erosions
ethanol
individual
irritation
ns
paint
pb
pe
penile
penis
podophyllin
regimens
resin
sequentially
superficial
supervised
tincture
treated
wart
warts
week
Tagcloud (Difference)
?
ascertain
benzoin
biweekly
break
clearance
clinic
convenience
eradicating
erosions
ethanol
individual
irritation
ns
paint
pb
pe
penile
penis
podophyllin
regimens
resin
sequentially
superficial
supervised
tincture
treated
wart
warts
week
Tagcloud (Intersection)
?