ITCH and RORA

Number of citations of the paper that reports this interaction (PubMedID 36114756)
58

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		ITCH	RORA
Description		itchy E3 ubiquitin protein ligase	RAR related orphan receptor A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Extracellular Exosome Cell Periphery	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ribonucleoprotein Complex Binding Ubiquitin-like Protein Ligase Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity Arrestin Family Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Ligand-modulated Transcription Factor Activity
	Biological Process	Protein Polyubiquitination Regulation Of Cell Growth Immune System Process Positive Regulation Of T Cell Anergy Negative Regulation Of Immune System Process Positive Regulation Of Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Inflammatory Response Response To Oxidative Stress Positive Regulation Of Catabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Protein Catabolic Process Receptor Internalization Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination CD4-positive, Alpha-beta T Cell Proliferation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Symbiont Entry Into Host Cell Negative Regulation Of Defense Response To Virus Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Protein Autoubiquitination Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination Protein Branched Polyubiquitination Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Receptor Catabolic Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Circadian Rhythm Regulation Of Smoothened Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Cholesterol Homeostasis Muscle Cell Differentiation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II CGMP Metabolic Process Rhythmic Process Negative Regulation Of Inflammatory Response Triglyceride Homeostasis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia T-helper 17 Cell Differentiation
Pathways		Downregulation of ERBB4 signaling NOD1/2 Signaling Pathway Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Degradation of GLI1 by the proteasome Hedgehog 'on' state Regulation of necroptotic cell death RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Cholesterol sulfate Cholesterol
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31015462 31152163) Fish- and plant-related diet ( 32066663) Heel bone mineral density ( 28869591) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Vitiligo ( 27723757)	A body shape index ( 34021172) Adult asthma ( 30787307) Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31619474 29273806 30929738 31959851 27182965 32296059 31361310 34103634 20860503) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Birth weight ( 31043758) Blood urea nitrogen levels ( 29403010 31152163) Body mass index ( 28892062) Breast cancer (prognosis) ( 23319801) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Cataracts ( 34127677) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic central serous retinopathy ( 30073298) Depression (quantitative trait) ( 20800221) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Eosinophilic esophagitis ( 34506852) Gamma glutamyl transferase levels ( 22010049) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 31211820) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Male-pattern baldness ( 28196072) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Menarche (age at onset) ( 21102462 23599027 25231870) Multiple sclerosis ( 31604244) Neuropathic pain in head and neck cancer ( 29884837) Nickel levels ( 26025379) Offspring birth weight ( 31043758) Pulmonary function decline ( 22424883) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to citalopram treatment ( 19846067) Reticulocyte count ( 32888494) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		132 interacting genes: AGO2 AKT1 ARHGEF7 ARID1A ARRB2 ARRDC3 ATN1 BECN1 BIN1 BRAF CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DSCR9 DTX1 DTX3L ERBB4 ESS2 EWSR1 FYN GJA1 GLIS3 GNAI2 H1-2 HNRNPUL1 JUN JUNB KIAA1210 KPNB1 KSR1 LAPTM5 LITAF LRRK1 MAP2 MAP2K1 MAP2K4 MAP3K2 MAPK8 MLANA MLKL MYCT1 N4BP1 NDFIP1 NDFIP2 NEDD9 NFE2 NOTCH1 NRAS NUDT21 NUMB PABPC1 PACSIN1 PIP4P2 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA PRRG4 RAF1 RBM14 REPS2 RHBDD1 RIPK1 RNF11 RORA RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL1 SH3GL2 SIK1 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SMN1 SNX9 SPART SPEN STAM2 STRIP2 SUFU TAB1 TAF15 TGFB1I1 TMEM51 TP73 TRERF1 TRPC4 TRPV1 TRPV4 TTYH3 UBAP2 UBAP2L UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2O UBE2Q1 UBE2Q2 UBE2R2 URI1 UVRAG WASL WBP2 YWHAQ YY1 ZC3H14	24 interacting genes: BHLHE41 COPS5 CSNK1E EP300 GFAP HIF1A ITCH LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 SP1 ZXDC
Entrez ID		83737	6095
HPRD ID		07565	02896
Ensembl ID		ENSG00000078747	ENSG00000069667
Uniprot IDs		Q96J02	A0A0C4DFP5 A0A0C4DG53 P35398
PDB IDs		2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 5C7M 5CQ2 5DWS 5DZD 5SXP	1N83 1S0X 4S15
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Nucleus Cytosol Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nucleotide Binding WW Domain Binding Regulation Of Primary Metabolic Process Protein Binding Intracellular Signal Transduction Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Cytoplasm Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Ubiquitination Negative Regulation Of Metabolic Process	Nuclear Receptor Binding Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Retinoic Acid Receptor Binding Regulation Of RNA Metabolic Process Transcription Coregulator Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Positive Regulation Of Developmental Process Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Lactation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Nucleoplasm Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process ITP Biosynthetic Process Protein Histidine Kinase Activity Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Chromatin Binding Body Fluid Secretion DNA-binding Transcription Factor Binding Protein Dimerization Activity Regulation Of Small Molecule Metabolic Process DNA-binding Transcription Activator Activity Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine
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