CSNK1A1 and AP3B1

Number of citations of the paper that reports this interaction (PubMedID 12062430)
0

Data Source:
HPRD (in vitro, in vivo)

		CSNK1A1	AP3B1
Description		casein kinase 1 alpha 1	adaptor related protein complex 3 subunit beta 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament	Mitochondrion Lysosomal Membrane Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Axon Cytoplasm Microvesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Protein Targeting Protein Targeting To Lysosome Intracellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Lung Development Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Protein Modification Process MRNA Transcription By RNA Polymerase II Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development Melanosome Assembly
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein	Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions
Drugs		Fostamatinib
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Insulin resistance/response ( 21901158) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)
Interacting Genes		51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ	13 interacting genes: AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 GKAP1 SLC30A3
Entrez ID		1452	8546
HPRD ID		02739	04551
Ensembl ID		ENSG00000113712	ENSG00000132842
Uniprot IDs		B4DER9 P48729 Q6PJ06	A0A0S2Z5J4 A0A8Q3SIM7 O00203
PDB IDs		5FQD 6GZD 7WTT 8G66	9C58 9C59 9C5A 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process	Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Histone H2AXS139 Kinase Activity Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Mitotic Nuclear Division Nucleotide Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Mitotic Sister Chromatid Separation Protein Serine/threonine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Meiotic Sister Chromatid Cohesion Negative Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Cell Division Negative Regulation Of Cell Cycle Phase Transition Spindle DNA Strand Resection Involved In Replication Fork Processing Vesicle-mediated Transport Regulation Of Chromosome Organization Replicative Senescence Regulation Of Cellular Response To Heat Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Kinase Activity Negative Regulation Of B Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Organization Intracellular Protein Transport Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Outer Kinetochore Intracellular Protein Localization Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Segregation Kinase Activity Protein Localization To Site Of Double-strand Break Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Cellular Response To Gamma Radiation Chromosome Organization
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