CSNK1A1 and GLI3

Number of citations of the paper that reports this interaction (PubMedID 16371461)
39

Data Source:
BioGRID (enzymatic study)

		CSNK1A1	GLI3
Description		casein kinase 1 alpha 1	GLI family zinc finger 3
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Axoneme Nuclear Speck Transcription Repressor Complex Cell Projection Ciliary Tip Ciliary Base GLI-SUFU Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Histone Acetyltransferase Binding Mediator Complex Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Kidney Development Positive Regulation Of Neuroblast Proliferation Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Smoothened Signaling Pathway Pattern Specification Process Neuroblast Proliferation Axon Guidance Central Nervous System Development Brain Development Hindgut Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Gene Expression Regulation Of Gene Expression Protein Processing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Telencephalon Development Pallium Development Subpallium Development Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia-guided Migration Layer Formation In Cerebral Cortex Forebrain Radial Glial Cell Differentiation Neural Tube Development Central Nervous System Neuron Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Embryonic Limb Morphogenesis Mammary Gland Development Forebrain Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Tube Development Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Camera-type Eye Development Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Negative Thymic T Cell Selection Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Embryonic Neurocranium Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Roof Of Mouth Development Limb Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Vocalization Behavior Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Larynx Morphogenesis Regulation Of Bone Development Negative Regulation Of Stem Cell Proliferation
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein	GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates osteoblast differentiation
Drugs		Fostamatinib
Diseases			Acrocallosal syndrome; Greig cephalopolysyndactyly syndrome Pallister-Hall syndrome
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)	Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096) Appendicular lean mass ( 33097823) Asthma ( 29273806) Dietary fat liking ( 32516399) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Emotional recognition ( 31596458) facial morphology traits (multivariate analysis) ( 27193062) Health literacy ( 31250787) Hip index ( 34021172) Language performance in older adults (adjusted for episodic memory) ( 28577822) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Metabolite levels ( 23823483) middle facial morphology traits (quantitative measurement) ( 27193062) Refractive error ( 32231278) Response to resistance training (vastus lateralis fiber area change) ( 33891350)
Interacting Genes		51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ	19 interacting genes: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA RHOU SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TAF9 TWIST1 ZIC1 ZIC2 ZIC3
Entrez ID		1452	2737
HPRD ID		02739	01313
Ensembl ID		ENSG00000113712	ENSG00000106571
Uniprot IDs		B4DER9 P48729 Q6PJ06	A0A2R8YGX0 P10071
PDB IDs		5FQD 6GZD 7WTT 8G66	4BLD
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process	Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription SMAD Protein Complex Heteromeric SMAD Protein Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process I-SMAD Binding Regulation Of Primary Metabolic Process Animal Organ Development Positive Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression DNA-binding Transcription Factor Binding Regulation Of Smoothened Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Endoderm Development Regulation Of Cell Communication Regulation Of Signaling Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Catabolic Process Tissue Morphogenesis Transcription Regulator Complex Gastrulation Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Co-SMAD Binding DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Primary MiRNA Processing RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regionalization Nucleoplasm
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