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CSNK1A1 and AXIN1
Number of citations of the paper that reports this interaction (PubMedID
17318175
)
56
Data Source:
HPRD
(in vitro, in vivo)
CSNK1A1
AXIN1
Description
casein kinase 1 alpha 1
axin 1
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Nucleus
Chromosome
Cytoplasm
Centrosome
Spindle
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Cytoskeleton
Cilium
Membrane
Nuclear Speck
Beta-catenin Destruction Complex
Ciliary Basal Body
Cell Projection
Keratin Filament
Nucleus
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Cell Periphery
Wnt Signalosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
P53 Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activator Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
R-SMAD Binding
Protein Serine/threonine Kinase Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Autophagosome Assembly
Protein Phosphorylation
Golgi Organization
Signal Transduction
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Wnt Signaling Pathway
Viral Protein Processing
Regulation Of Wnt Signaling Pathway
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Nutrient Levels
Cellular Response To Nutrient
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Rho Protein Signal Transduction
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
NLRP3 Inflammasome Complex Assembly
Intermediate Filament Cytoskeleton Organization
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Protein Polyubiquitination
In Utero Embryonic Development
Nucleocytoplasmic Transport
Apoptotic Process
Sensory Perception Of Sound
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Protein Catabolic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytoplasmic Microtubule Organization
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Post-anal Tail Morphogenesis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of JNK Cascade
Axial Mesoderm Development
Axial Mesoderm Formation
Cell Development
Negative Regulation Of Protein Metabolic Process
Canonical Wnt Signaling Pathway
Head Development
Regulation Of Canonical Wnt Signaling Pathway
Protein-containing Complex Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Activation of SMO
Activation of SMO
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Maturation of nucleoprotein
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
Fostamatinib
1,4-Dithiothreitol
Diseases
Caudal duplication anomaly
Hepatocellular carcinoma
GWAS
Carotid intima media thickness x smoking interaction (
32117412
)
Chronic obstructive pulmonary disease (
30804561
)
Esophageal cancer (
21642993
)
Adult body size (
32376654
)
Appendicular lean mass (
33097823
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Iron status biomarkers (ferritin levels) (
33536631
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics (
32958699
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Interacting Genes
51 interacting genes:
ACTB
ADAP1
AP3B1
AP3B2
APC
ATM
AXIN1
BID
CDC25A
CEBPA
CHRM3
CRBN
CREM
CTNNB1
CUL4B
EIF2B5
ERF
FADD
GLI3
GNB2
HMGB1
HMGB2
HNRNPC
HSPA4
KPNA2
KPNB1
LGALS3
MDM4
NFATC3
NLRP3
OCLN
PDE4D
PHLPP1
PPP1CC
PPP1R14A
PPP2R5A
PSEN2
PTEN
RCC1
SLC18A2
SNCA
SQSTM1
SYT9
TGFBR1
TIAM1
TNFRSF1B
TP53
USP15
UVRAG
YWHAQ
YWHAZ
91 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
FXR1
FXR2
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KAT5
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RCHY1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TNKS
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSC1
TSGA10
UCHL5
USP10
USP7
UTP14A
WSB1
ZBTB26
ZFYVE19
Entrez ID
1452
8312
HPRD ID
02739
04819
Ensembl ID
ENSG00000113712
ENSG00000103126
Uniprot IDs
B4DER9
P48729
Q6PJ06
A0A0S2Z4R0
A0A0S2Z4S3
O15169
PDB IDs
5FQD
6GZD
7WTT
8G66
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
7SXF
7SXG
7SXH
7SXJ
7Y1P
8RU3
8RU4
8VMG
Enriched GO Terms of Interacting Partners
?
Protein-containing Complex
Signal Transduction
Regulation Of Apoptotic Process
Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Immune System Process
Regulation Of Cell Development
Ubiquitin Protein Ligase Binding
Protein Domain Specific Binding
Regulation Of Cell Activation
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cell Development
Cytosol
Negative Regulation Of Signal Transduction
Positive Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Cellular Component Assembly
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cell Differentiation
Regulation Of RNA Metabolic Process
Regulation Of T Cell Activation
Regulation Of Metabolic Process
Regulation Of Stem Cell Proliferation
T Cell Differentiation In Thymus
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Differentiation
Regulation Of Lymphocyte Activation
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Hemopoiesis
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Catabolic Process
Regulation Of Cell Population Proliferation
Lung Development
Regulation Of Cellular Component Organization
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of DNA-templated Transcription
Intracellular Signaling Cassette
Cytoplasm
Regulation Of Organelle Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Apoptotic Process
Wnt Signaling Pathway
Cytoplasm
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signal Transduction
Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Catabolic Process
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Wnt Signalosome
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Post-translational Protein Modification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Component Organization
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Beta-catenin Destruction Complex
Signal Transduction
Beta-catenin Binding
PML Body
Positive Regulation Of Biosynthetic Process
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