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CSNK1A1 and PPP2R5A
Number of citations of the paper that reports this interaction (PMID
12062430
)
3
Data Source:
HPRD
(in vitro)
CSNK1A1
PPP2R5A
Gene Name
casein kinase 1, alpha 1
protein phosphatase 2, regulatory subunit B, alpha
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Condensed Chromosome Kinetochore
Cytoplasm
Centrosome
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Membrane
Nuclear Speck
Primary Cilium
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Cytoplasm
Membrane
Z Disc
M Band
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Kinase Binding
Biological Process
Protein Phosphorylation
Phagocytosis
Mitotic Nuclear Division
Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Shape
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Cell Division
Positive Regulation Of Canonical Wnt Signaling Pathway
Signal Transduction
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Negative Regulation Of Lipid Kinase Activity
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
RNF mutants show enhanced WNT signaling and proliferation
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
Hedgehog 'on' state
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
AMER1 mutants destabilize the destruction complex
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by Hedgehog
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Activation of SMO
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Mitotic Anaphase
Signaling by Wnt
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Degradation of beta-catenin by the destruction complex
S37 mutants of beta-catenin aren't phosphorylated
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
CTLA4 inhibitory signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Cell Cycle, Mitotic
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Esophageal cancer (
21642993
)
Protein-Protein Interactions
43 interactors:
ACTB
ADAP1
AP3B1
AP3B2
APC
AXIN1
BID
CDC25A
CHRM3
CREM
CTNNB1
EIF2B5
ERF
FADD
GLI3
GNB2
HMGB1
HMGB2
HNRNPC
HSPA4
KPNA2
KPNB1
LGALS3
MAPT
MDM4
NFATC3
PARK2
PDE4D
PHLPP1
PPP1CC
PPP1R14A
PPP2R5A
PSEN2
RCC1
SLC18A2
SNCA
SYT9
TGFBR1
TIAM1
TNFRSF1B
TP53
YWHAQ
YWHAZ
18 interactors:
APC
BCL2
BEST1
CHEK2
CSNK1A1
CTLA4
EIF2AK2
GNL3
JAK2
MAPT
NEK1
NOS3
PPP2R1A
PTTG1
PYGM
SGOL1
SHC1
TP63
Entrez ID
1452
5525
HPRD ID
02739
03384
Ensembl ID
ENSG00000113712
ENSG00000066027
Uniprot IDs
B4DER9
P48729
Q6PJ06
Q71TU5
Q15172
PDB IDs
Enriched GO Terms of Interacting Partners
?
Death
Apoptotic Process
Programmed Cell Death
Cell Death
Cellular Response To Stimulus
Regulation Of Cellular Localization
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Signaling
Positive Regulation Of Cell Death
Response To Organic Substance
Response To Stimulus
Cell Communication
Regulation Of Apoptotic Process
Response To Stress
Regulation Of Cell Death
Regulation Of Protein Localization
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Regulation Of Cellular Process
Regulation Of Signaling
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Intracellular Transport
Execution Phase Of Apoptosis
Response To External Stimulus
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Death
Immune System Process
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Activation
Regulation Of Establishment Of Protein Localization
Developmental Process
Thymus Development
Regulation Of Catalytic Activity
Signal Transduction
Cellular Response To Organic Substance
Positive Regulation Of Metabolic Process
Positive Regulation Of Mitochondrion Organization
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
T Cell Differentiation In Thymus
Regulation Of Cellular Component Organization
Regulation Of Protein Complex Assembly
Regulation Of Cellular Protein Metabolic Process
Leukocyte Activation
Positive Regulation Of Protein Metabolic Process
Movement Of Cell Or Subcellular Component
Mitotic Cell Cycle Process
Cell Division
Organelle Organization
Cellular Response To Stress
Mitotic Cell Cycle
Regulation Of Protein Metabolic Process
Mitotic Nuclear Division
Positive Regulation Of Signal Transduction
Cell Cycle Process
Regulation Of Cell Proliferation
Cellular Response To DNA Damage Stimulus
Regulation Of Catalytic Activity
Cell Cycle
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Response To Ionizing Radiation
Apoptotic Process
Positive Regulation Of Cell Death
Regulation Of MAPK Cascade
Regulation Of Cellular Protein Metabolic Process
Regulation Of Apoptotic Process
Programmed Cell Death
Regulation Of Phosphorus Metabolic Process
Cell Death
Negative Regulation Of Cell Proliferation
Death
Response To Stress
Regulation Of Protein Phosphorylation
Regulation Of Cell Death
Regulation Of Signal Transduction
Response To Gamma Radiation
Regulation Of Cell Differentiation
Cytoskeleton Organization
Intrinsic Apoptotic Signaling Pathway
Regulation Of Protein Kinase Activity
Positive Regulation Of Apoptotic Signaling Pathway
Response To Radiation
Regulation Of Kinase Activity
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Signaling
Cell Aging
Regulation Of Cell Cycle Phase Transition
Regulation Of Phosphorylation
Protein Phosphorylation
Intracellular Signal Transduction
Negative Regulation Of Osteoblast Proliferation
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Activation Of Protein Kinase Activity
Tagcloud
?
aberrantly
antagonistic
beauty
becomes
canonical
concert
connectivity
ctnnb1
decipher
discover
facts
functioning
gbm
gli2
hedgehog
imperative
integrative
interplay
missed
ranked
recapitulate
relying
shh
similarities
smo
solve
sonic
surmised
wnt
Tagcloud (Difference)
?
aberrantly
antagonistic
beauty
becomes
canonical
concert
connectivity
ctnnb1
decipher
discover
facts
functioning
gbm
gli2
hedgehog
imperative
integrative
interplay
missed
ranked
recapitulate
relying
shh
similarities
smo
solve
sonic
surmised
wnt
Tagcloud (Intersection)
?