CSNK1A1 and NFATC3

Number of citations of the paper that reports this interaction (PMID 9630228)
79

Data Source:
HPRD (in vitro, in vivo)

		CSNK1A1	NFATC3
Gene Name		casein kinase 1, alpha 1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding
	Biological Process	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway	Patterning Of Blood Vessels Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response Heart Development Fc-epsilon Receptor Signaling Pathway Innate Immune Response Cellular Respiration Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Muscle Cell Development Cellular Response To Calcium Ion Cellular Response To Lithium Ion
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO	Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System
Drugs
Diseases
GWAS		Esophageal cancer ( 21642993)
Protein-Protein Interactions		43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ	6 interactors: CDK6 CSNK1A1 FOS MAPK8 MAPK9 TTF1
Entrez ID		1452	4775
HPRD ID		02739	04077
Ensembl ID		ENSG00000113712	ENSG00000072736
Uniprot IDs		B4DER9 P48729 Q6PJ06 Q71TU5	B5B2S0 B5B2S1 B5B2S3 B5B2S4 I3L3K7 Q12968
PDB IDs			2XRW 2XS0
Enriched GO Terms of Interacting Partners?		Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway JUN Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Circadian Rhythm Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Gene Expression Positive Regulation Of Innate Immune Response Response To Other Organism Response To Biotic Stimulus Response To Mechanical Stimulus Response To External Stimulus MAPK Cascade Fc-epsilon Receptor Signaling Pathway Phosphorylation Regulation Of Innate Immune Response Fc Receptor Signaling Pathway Signal Transduction By Phosphorylation Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Metal Ion Response To Molecule Of Bacterial Origin Response To Light Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Cadmium Ion Regulation Of Immune System Process Response To Radiation Protein Phosphorylation Hippocampus Development Immune Response-regulating Signaling Pathway Response To Inorganic Substance Regulation Of Cell Morphogenesis Response To Bacterium Signaling JNK Cascade Cell Communication
Tagcloud ?		aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt	acting aortic basally cardiomyocyte cardiomyocytes complimentary concert constriction coupled desensitize exaggerated exert facilitator failing grk2 grk5 grks hypertrophic hypertrophy maladaptive myocardium myocytes nucleus participates phenylephrine rationale reside transverse
Tagcloud (Difference) ?		aberrantly antagonistic beauty becomes canonical connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt	acting aortic basally cardiomyocyte cardiomyocytes complimentary constriction coupled desensitize exaggerated exert facilitator failing grk2 grk5 grks hypertrophic hypertrophy maladaptive myocardium myocytes nucleus participates phenylephrine rationale reside transverse
Tagcloud (Intersection) ?		concert