CSNK1A1 and YWHAZ

Number of citations of the paper that reports this interaction (PMID 9360956)
19

Data Source:
HPRD (in vivo)

		CSNK1A1	YWHAZ
Gene Name		casein kinase 1, alpha 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Postsynaptic Density Cytoplasmic Vesicle Membrane Cell Leading Edge Melanosome Mast Cell Granule Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Domain Specific Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway	Histamine Secretion By Mast Cell Protein Targeting To Mitochondrion Apoptotic Process Signal Transduction Blood Coagulation Gene Expression Platelet Activation Response To Drug Negative Regulation Of Apoptotic Process Establishment Of Golgi Localization Membrane Organization Golgi Reassembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO	Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Signaling by Wnt deactivation of the beta-catenin transactivating complex Rap1 signalling RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytokine Signaling in Immune system Activation of BAD and translocation to mitochondria Signaling by Interleukins TCF dependent signaling in response to WNT KSRP destabilizes mRNA GP1b-IX-V activation signalling Signaling by WNT in cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs
Diseases
GWAS		Esophageal cancer ( 21642993)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ	191 interactors: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARAF ARHGEF2 ATP5A1 ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CFL1 CGNL1 CLIC4 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EPB41L1 EPB41L2 EPB41L3 EXO1 FAM13B FAM53C FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 HDAC4 HDAC9 HIST1H3A HIVEP2 HMGN1 HSPA1A HSPA1B IGF1R IL9R ING1 INPP5A IRS1 IRS2 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIAA1377 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LCP2 LIMK1 LRMP LYST MADD MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PRDX2 PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RFWD2 RGS3 RIN1 RMDN3 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNX24 SORBS2 SQSTM1 SSFA2 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YWHAE ZAK ZNF839
Entrez ID		1452	7534
HPRD ID		02739	03183
Ensembl ID		ENSG00000113712	ENSG00000164924
Uniprot IDs		B4DER9 P48729 Q6PJ06 Q71TU5	D0PNI1 P63104
PDB IDs			1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL
Enriched GO Terms of Interacting Partners?		Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component	Intracellular Signal Transduction Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Signal Transduction Regulation Of Kinase Activity Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Response To Stress Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction Protein Phosphorylation Neurotrophin Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Organic Substance Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Death Regulation Of MAPK Cascade Apoptotic Process Cell Death Death Programmed Cell Death Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization
Tagcloud ?		aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt	actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2
Tagcloud (Difference) ?		aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt	actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2
Tagcloud (Intersection) ?