CSNK1A1 and AP3B2

Number of citations of the paper that reports this interaction (PubMedID 10930456)
71

Data Source:
HPRD (in vitro, in vivo)

		CSNK1A1	AP3B2
Description		casein kinase 1 alpha 1	adaptor related protein complex 3 subunit beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament	Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Vesicle Presynapse Axon Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Intracellular Protein Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Synaptic Vesicle Endocytosis Anterograde Synaptic Vesicle Transport
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein
Drugs		Fostamatinib
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)	Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Schizophrenia ( 28991256) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ	7 interacting genes: ADAP1 AP3S1 ATM CLTC CSNK1A1 ERBB2 RUFY1
Entrez ID		1452	8120
HPRD ID		02739	03699
Ensembl ID		ENSG00000113712	ENSG00000103723
Uniprot IDs		B4DER9 P48729 Q6PJ06	F5GYB0 Q13367
PDB IDs		5FQD 6GZD 7WTT 8G66
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process	Intracellular Membrane-bounded Organelle Positive Regulation Of Rho Protein Signal Transduction Spindle Establishment Of RNA Localization To Telomere Autophagosome Assembly Negative Regulation Of TOR Signaling Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of TORC1 Signaling Protein Phosphorylation Regulation Of TORC1 Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Leukocyte Proliferation Autophagosome Organization Negative Regulation Of Mononuclear Cell Proliferation Cytoplasmic Vesicle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Phosphorylation Intracellular Protein Localization Protein Kinase Activity Retrograde Transport, Endosome To Golgi Regulation Of Rho Protein Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction ERBB3:ERBB2 Complex Regulation Of Cellular Component Organization DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Cytosolic Transport RNA Polymerase I Core Binding Vacuole Organization Negative Regulation Of Lymphocyte Activation Positive Regulation Of Autophagy Cellular Response To Nitrosative Stress Regulation Of TOR Signaling Peptidyl-serine Autophosphorylation Signal Transduction Kinase Activity Pre-B Cell Allelic Exclusion Cellular Localization AP-type Membrane Coat Adaptor Complex Synaptic Vesicle Coating Cytoplasmic Vesicle Membrane Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Disassembly Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Inositol 1,3,4,5 Tetrakisphosphate Binding Organelle Assembly
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