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GIT2 and GIT1
Number of citations of the paper that reports this interaction (PubMedID
40437099
)
172
Data Source:
BioGRID
(cross-linking study)
HPRD
(in vivo, two hybrid, in vitro)
GIT2
GIT1
Description
GIT ArfGAP 2
GIT ArfGAP 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Focal Adhesion
Synapse
Presynapse
Spindle Pole
Cytoplasm
Mitochondrion
Endosome
Centrosome
Cytosol
Cytoskeleton
Focal Adhesion
Postsynaptic Density
Membrane
Lamellipodium
Dendrite
Growth Cone
Cell Projection
Neuron Projection
Calyx Of Held
Synapse
Excitatory Synapse
Inhibitory Synapse
Anchoring Junction
Mitotic Spindle Pole
Presynapse
Postsynapse
Glutamatergic Synapse
GABA-ergic Synapse
Molecular Function
GTPase Activator Activity
Protein Binding
Zinc Ion Binding
Small GTPase Binding
Metal Ion Binding
GTPase Activator Activity
Protein Binding
Zinc Ion Binding
Protein Phosphatase Binding
Small GTPase Binding
Identical Protein Binding
Gamma-tubulin Binding
Protein-containing Complex Binding
Metal Ion Binding
Scaffold Protein Binding
Structural Constituent Of Postsynaptic Specialization
Protein Tyrosine Kinase Binding
Biological Process
Brain Development
Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of ARF Protein Signal Transduction
Synaptic Vesicle Recycling
Immunological Synapse Formation
Intramembranous Ossification
Brain Development
Locomotory Behavior
Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of ARF Protein Signal Transduction
Negative Regulation Of ARF Protein Signal Transduction
Regulation Of Cytokinesis
Negative Regulation Of Interleukin-1 Beta Production
Synaptic Vesicle Recycling
Cell Redox Homeostasis
Negative Regulation Of Glycolytic Process
Ephrin Receptor Signaling Pathway
Neuron Development
Dendritic Spine Development
Motor Learning
Cellular Response To Lipopolysaccharide
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Microtubule Nucleation
Maintenance Of Postsynaptic Specialization Structure
Presynaptic Modulation Of Chemical Synaptic Transmission
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Negative Regulation Of Inflammatory Response To Wounding
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Receptor Catabolic Process
Pathways
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Ephrin signaling
Ephrin signaling
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Activation of RAC1 downstream of NMDARs
Drugs
Diseases
GWAS
Bipolar disorder (
31043756
)
Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia (
28922980
)
Metabolic syndrome (
20694148
)
Metabolite levels (
23823483
)
Metabolite levels (MHPG) (
23319000
)
Adult body size (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
47 interacting genes:
ACTG1
ACTN1
ARHGEF7
ATF5
C4BPA
CALCOCO2
CDC42
CORO1A
E2F2
EDC4
GCH1
GET4
GIT1
GRK2
GUSB
HGD
HNRNPUL1
IKBKG
KCTD5
KRT18
LAMTOR5
LMNB1
MVP
NFKBIB
NME2
PAK1
PAK3
PCLO
POLR1B
PROX1
PXN
QPRT
RCVRN
RUFY1
RUSC2
SAFB2
SH3GLB2
SMAD3
SPOP
TGFB1I1
TNFAIP3
TNIP1
TRAF1
TSN
UBQLN1
USHBP1
YWHAG
54 interacting genes:
ARHGEF6
ARHGEF7
BARD1
C8orf33
CENPU
CEP126
CFAP263
CHD3
DDX24
DSCR9
EIF6
ENTR1
GIT2
GRB2
GRK2
GRK3
GRK5
GRK6
HAP1
HMOX2
HSPA13
HTT
KIF1A
KLHL4
LAMTOR5
LPXN
LRIF1
MAN2A2
NEK2
PAK3
PCLO
PDPK1
PFDN1
PLCG1
PMF1
PPFIA1
PPFIA2
PPFIA3
PPFIA4
PTK2
PTPRZ1
PXN
RAN
RGS2
RIF1
SRC
SRRT
TAB1
TERF1
TGFB1I1
TRIB3
TXNDC9
WDR33
YWHAG
Entrez ID
9815
28964
HPRD ID
09779
06577
Ensembl ID
ENSG00000139436
ENSG00000108262
Uniprot IDs
F8VXI9
F8W822
Q14161
Q6FI58
Q59FC3
Q9Y2X7
PDB IDs
Enriched GO Terms of Interacting Partners
?
Identical Protein Binding
Cytosol
Regulation Of Supramolecular Fiber Organization
Cytoplasm
Focal Adhesion
Regulation Of Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Organization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament-based Process
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Cytoskeleton Organization
Lamellipodium
Ephrin Receptor Signaling Pathway
Cell-cell Junction
Regulation Of Microtubule Nucleation
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Organization
Regulation Of Lung Blood Pressure
Actin Cytoskeleton Organization
Regulation Of Signal Transduction
Actin Filament
Cytoskeleton
Gamma-tubulin Binding
Actin Filament-based Process
Response To Type II Interferon
Regulation Of Intracellular Signal Transduction
Ruffle
Positive Regulation Of Microtubule Nucleation
Regulation Of Canonical NF-kappaB Signal Transduction
Postsynapse Organization
Extracellular Exosome
Cytoskeleton Organization
Regulation Of Organelle Organization
Profilin Binding
Signal Transduction
Thioesterase Binding
Neuron Fate Determination
Regulation Of Apoptotic Process
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Organelle Organization
Vinculin Binding
Regulation Of Programmed Cell Death
Ameboidal-type Cell Migration
Regulation Of Toll-like Receptor 3 Signaling Pathway
Cell Surface Receptor Signaling Pathway
Immunological Synapse Formation
Beta-adrenergic Receptor Kinase Activity
G Protein-coupled Receptor Kinase Activity
Cytoplasm
Presynaptic Active Zone
Focal Adhesion
Cell Projection
Epidermal Growth Factor Receptor Signaling Pathway
Signal Complex Assembly
Cytoskeleton
Cytosol
ERBB Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Synapse
Centrosome
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Regulation Of G Protein-coupled Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Organelle Localization
Transforming Growth Factor Beta Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Kinase Activity
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Kinase Activity
Vesicle Cytoskeletal Trafficking
Positive Regulation Of Calcium Ion Transmembrane Transport
Vesicle Localization
Protein Autophosphorylation
Centriolar Satellite
ATP Binding
Cell Junction Organization
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cell-substrate Adhesion
Protein-containing Complex
Cellular Response To Fluid Shear Stress
Synapse Organization
Positive Regulation Of Cilium Assembly
Negative Adaptation Of Signaling Pathway
Positive Regulation Of Lamellipodium Morphogenesis
Establishment Of Organelle Localization
Positive Regulation Of Organelle Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Protein Phosphatase Binding
Tachykinin Receptor Signaling Pathway
Regulation Of Cell Communication
Protein Serine/threonine Kinase Activity
Regulation Of Signaling
Regulation Of Cell Projection Organization
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Tagcloud (Difference)
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Tagcloud (Intersection)
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