GIT1 and SRRT

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GIT1	SRRT
Description		GIT ArfGAP 1	serrate, RNA effector molecule
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm Cytoplasm Nuclear Body Protein-containing Complex Ribonucleoprotein Complex
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Protein-macromolecule Adaptor Activity MRNA Cap Binding Complex Binding
	Biological Process	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process	Regulation Of DNA-templated Transcription Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Neuronal Stem Cell Population Maintenance
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway Nuclear RNA decay
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Hemoglobin levels ( 32327693) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 27798624) RR interval (heart rate) ( 30679814)
Interacting Genes		54 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	16 interacting genes: APP CACNA1C CHD3 CSNK2A1 GEMIN4 GIT1 HNRNPK HSPA8 HTR6 IMMT LINC00624 SNRPF STAT3 SUMO2 VAV2 VIM
Entrez ID		28964	51593
HPRD ID		06577	10665
Ensembl ID		ENSG00000108262	ENSG00000087087
Uniprot IDs		Q59FC3 Q9Y2X7	Q9BXP5
PDB IDs			5OO6 6F7J 6F7P 6F7S 6F8D 8PMP
Enriched GO Terms of Interacting Partners?		Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization	Regulation Of Protein Import Regulation Of Glycolytic Process MRNA Metabolic Process Regulation Of Carbohydrate Catabolic Process RNA Binding Negative Regulation Of Inflammatory Response To Wounding Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Inflammatory Response To Wounding Protein Targeting To Vacuole Involved In Autophagy Regulation Of Interleukin-1 Beta Production Small Nuclear Ribonucleoprotein Complex Positive Regulation Of Catabolic Process SMN-Sm Protein Complex Regulation Of Interleukin-1 Production PML Body Negative Regulation Of Glycolytic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of ATP Metabolic Process RNA Splicing Astrocyte Differentiation Positive Regulation Of ATP Metabolic Process Spliceosomal Complex Focal Adhesion MRNA Processing Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Dendrite Amylin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll Signaling Pathway RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Chaperone-mediated Autophagy Translocation Complex Disassembly Spliceosomal SnRNP Assembly Negative Regulation Of ARF Protein Signal Transduction Protein Targeting To Vacuole Regulation Of Biological Quality RNA Metabolic Process Presynapse Postsynapse Regulation Of Cellular Response To Stress Positive Regulation Of Interleukin-1 Beta Production Acetylcholine Receptor Activator Activity Regulation Of Multicellular Organism Growth Lipoprotein Particle Positive Regulation Of Protein Import
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