GIT2 and ATF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GIT2	ATF5
Description		GIT ArfGAP 2	activating transcription factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion Synapse Presynapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Cytoskeleton RNA Polymerase II Transcription Regulator Complex
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Tubulin Binding Kinase Binding Sequence-specific DNA Binding
	Biological Process	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Negative Regulation Of Cell Population Proliferation Post-embryonic Development Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Olfactory Bulb Interneuron Development Cerebellar Granule Cell Precursor Proliferation Olfactory Lobe Development Multicellular Organism Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centrosome Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Response of EIF2AK1 (HRI) to heme deficiency Mitochondrial unfolded protein response (UPRmt) Mitochondrial unfolded protein response (UPRmt)
Drugs			Pseudoephedrine
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	18 interacting genes: ATXN1 CCDC6 CCND3 CDC34 CEBPA CEBPE CEBPG DISC1 EIF2B1 EP300 FBXO7 GABBR1 GABBR2 GIT2 GPS2 KEAP1 SYCE1L TTR
Entrez ID		9815	22809
HPRD ID		09779	05906
Ensembl ID		ENSG00000139436	ENSG00000169136
Uniprot IDs		F8VXI9 F8W822 Q14161 Q6FI58	Q9Y2D1
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation	Mononuclear Cell Differentiation G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Leukocyte Differentiation GABA Receptor Complex Integrated Stress Response Signaling Neuron-glial Cell Signaling GABA Receptor Activity Identical Protein Binding STAT Family Protein Binding DNA-templated Transcription Lymphocyte Activation Protein-containing Complex Myeloid Cell Differentiation Lymphocyte Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Leukocyte Activation Signal Transduction B Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Gamma-aminobutyric Acid Signaling Pathway Protein Heterodimerization Activity Granulocyte Differentiation Protein-containing Complex Binding Cell Activation Synaptic Transmission, GABAergic Nucleoplasm Regulation Of Cell Differentiation Macrophage Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding B Cell Activation Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite
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