GIT2 and KCTD5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GIT2	KCTD5
Description		GIT ArfGAP 2	potassium channel tetramerization domain containing 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion Synapse Presynapse	Nucleus Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding Cullin Family Protein Binding
	Biological Process	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	7 interacting genes: CD1A EP300 GIT2 GORASP2 NEK6 NXF1 PRKAB2
Entrez ID		9815	54442
HPRD ID		09779	13768
Ensembl ID		ENSG00000139436	ENSG00000167977
Uniprot IDs		F8VXI9 F8W822 Q14161 Q6FI58	Q9NXV2
PDB IDs			3DRX 3DRY 3DRZ 8U7Z 8U80 8U81 8U82 8U83 8U84
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation	Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Exogenous Lipid Antigen Binding Endogenous Lipid Antigen Binding Negative Regulation Of Protein Oligomerization
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