GIT1 and PXN

Number of citations of the paper that reports this interaction (PubMedID 16628223)
42

Data Source:
HPRD (in vivo)

		GIT1	PXN
Description		GIT ArfGAP 1	paxillin
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		54 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	86 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN
Entrez ID		28964	5829
HPRD ID		06577	03937
Ensembl ID		ENSG00000108262	ENSG00000089159
Uniprot IDs		Q59FC3 Q9Y2X7	A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023
PDB IDs			1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0
Enriched GO Terms of Interacting Partners?		Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization	Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway
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