GIT1 and C8orf33

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GIT1	C8orf33
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 1	chromosome 8 open reading frame 33
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway
Pathways		Ephrin signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	41 interactors: AAMP ALAS1 APP BLOC1S2 BRD4 CEP70 CRELD2 DVL3 EDRF1 EPS8 FAM9B FEZ1 FST FYN GIT1 GPRASP1 HAP1 HMBOX1 IKZF1 IMMT KBTBD7 KCTD6 KRTAP10-7 LZTS2 MDFI MRFAP1 NGEF NOL7 PI4KA PNMA1 RASSF1 SF3B2 TAOK1 TRIM23 TUBA1A TUBB2B WIZ ZC3H15 ZFP28 ZNF205 ZNF331
Entrez ID		28964	65265
HPRD ID		06577	07951
Ensembl ID		ENSG00000108262	ENSG00000182307
Uniprot IDs		Q59FC3 Q9Y2X7	Q9H7E9
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation	Cell Cycle Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Signaling Axon Cargo Transport Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Axon Guidance Positive Regulation Of Cell Cycle Process Locomotion Positive Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Cell Morphogenesis Protein Polymerization Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of JNK Cascade Positive Regulation Of Cell Cycle Microtubule-based Process Anterograde Axon Cargo Transport Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Axonogenesis Microtubule-based Transport Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Neuron Projection Development Intracellular Signal Transduction Cell Projection Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation System Development Cellular Protein Complex Assembly Generation Of Neurons Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Signal Transduction Chemotaxis Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Intersection) ?