GIT2 and EDC4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GIT2	EDC4
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 2	enhancer of mRNA decapping 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Behavioral Response To Pain	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways			mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148) Metabolite levels (MHPG) ( 23319000)	Coronary heart disease ( 21347282) Metabolic syndrome ( 22399527)
Protein-Protein Interactions		44 interactors: ACTG1 ACTN1 ADRBK1 ARHGEF7 ATF5 C4BPA CALCOCO2 CORO1A E2F2 EDC4 GCH1 GIT1 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	5 interactors: CCL5 EIF2AK2 FBLN1 GIT2 YTHDC1
Entrez ID		9815	23644
HPRD ID		09779	06911
Ensembl ID		ENSG00000139436	ENSG00000038358
Uniprot IDs		F8VXI9 Q14161 Q6FI58	Q6P2E9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Ephrin Receptor Signaling Pathway Innate Immune Response Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of Immune System Process Cell Death Regulation Of Metabolic Process Death Positive Regulation Of Immune Response Defense Response Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Adherens Junction Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Focal Adhesion Assembly Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Signaling Regulation Of Kinase Activity Cellular Component Assembly Cell Communication Regulation Of Phosphorylation Adherens Junction Assembly Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Development Cell-substrate Junction Assembly Activation Of MAPK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Stress Activation Of Innate Immune Response Cell Surface Receptor Signaling Pathway	Negative Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Positive Regulation Of Catalytic Activity Regulation Of Translational Initiation Negative Regulation Of Viral Process Evasion Or Tolerance By Virus Of Host Immune Response Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Viral Process Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Hydrolase Activity Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Activation Of JAK2 Kinase Activity Response To Virus Positive Regulation Of Protein Metabolic Process Regulation Of Translation Positive Regulation Of Activation Of Janus Kinase Activity Response To Host Immune Response Positive Regulation Of Macrophage Chemotaxis Regulation Of NLRP3 Inflammasome Complex Assembly Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of T Cell Chemotaxis Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Metabolic Process Negative Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Chemotaxis Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Osteoblast Proliferation Modulation By Virus Of Host Process Regulation Of Chronic Inflammatory Response Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Positive Regulation Of Translational Initiation Dendritic Cell Chemotaxis Activation Of Phospholipase D Activity Positive Regulation Of T Cell Apoptotic Process Monocyte Chemotaxis Regulation Of Macrophage Apoptotic Process Regulation Of Translation In Response To Stress Response To Interferon-alpha Posttranscriptional Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	bodies coimmunoprecipitated collectively colocalized dcp1a decapping dispersion effectors ikappabalpha inducers jnk jun localization messenger multifunctional overexpressed p65 phosphomimetic residue ribonucleic s315 stabilized stimuli subcellular sustained tak1 transcriptome transiently xrn1
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	bodies coimmunoprecipitated collectively colocalized dcp1a decapping dispersion effectors ikappabalpha inducers jnk jun localization messenger multifunctional overexpressed p65 phosphomimetic residue ribonucleic s315 stabilized stimuli subcellular sustained tak1 transcriptome transiently xrn1
Tagcloud (Intersection) ?