GIT2 and SH3GLB2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GIT2	SH3GLB2
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 2	SH3-domain GRB2-like endophilin B2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Behavioral Response To Pain
Pathways
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148) Metabolite levels (MHPG) ( 23319000)
Protein-Protein Interactions		44 interactors: ACTG1 ACTN1 ADRBK1 ARHGEF7 ATF5 C4BPA CALCOCO2 CORO1A E2F2 EDC4 GCH1 GIT1 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	8 interactors: CCDC158 GADD45G GIT2 KDM1A MAGEA1 SH3GLB1 SH3KBP1 SREK1
Entrez ID		9815	56904
HPRD ID		09779	15334
Ensembl ID		ENSG00000139436	ENSG00000148341
Uniprot IDs		F8VXI9 Q14161 Q6FI58	B7ZC38 Q9NR46
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Ephrin Receptor Signaling Pathway Innate Immune Response Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of Immune System Process Cell Death Regulation Of Metabolic Process Death Positive Regulation Of Immune Response Defense Response Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Adherens Junction Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Focal Adhesion Assembly Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Signaling Regulation Of Kinase Activity Cellular Component Assembly Cell Communication Regulation Of Phosphorylation Adherens Junction Assembly Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Development Cell-substrate Junction Assembly Activation Of MAPK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Stress Activation Of Innate Immune Response Cell Surface Receptor Signaling Pathway	Regulation Of Primitive Erythrocyte Differentiation Regulation Of Signal Transduction Regulation Of Signaling Apoptotic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Programmed Cell Death Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Cell Death Death Negative Regulation Of Signal Transduction Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of P38MAPK Cascade Granulocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Positive Regulation Of Protein Oligomerization Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Behavioral Response To Pain Regulation Of Histone H3-K4 Methylation
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	analyse code crat ctsd ejaculated ejaculates elongating fertile fertilisation flna g6pd gapdh h3k9ac infertile intergenic mcf2l plxna3 protamines semen semiquantitative sox2 sperm spermatids spermatocytes spermatogenesis spermatogonia spermatozoa stk11ip testicular
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	analyse code crat ctsd ejaculated ejaculates elongating fertile fertilisation flna g6pd gapdh h3k9ac infertile intergenic mcf2l plxna3 protamines semen semiquantitative sox2 sperm spermatids spermatocytes spermatogenesis spermatogonia spermatozoa stk11ip testicular
Tagcloud (Intersection) ?