GIT2 and PAK3

Number of citations of the paper that reports this interaction (PubMedID 10896954)
0

Data Source:
HPRD (in vivo)

		GIT2	PAK3
Description		GIT ArfGAP 2	p21 (RAC1) activated kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion Synapse Presynapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Cellular Response To Starvation Dendrite Development Cell Migration Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Development Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Regulation Of Actin Filament Organization
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle
Drugs			Fostamatinib
Diseases			Non-syndromic X-linked mental retardation
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1
Entrez ID		9815	5063
HPRD ID		09779	02142
Ensembl ID		ENSG00000139436	ENSG00000077264
Uniprot IDs		F8VXI9 F8W822 Q14161 Q6FI58	B2RCU6 O75914
PDB IDs			6FD3
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation	Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Lamellipodium Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Cell Cortex Lamellipodium Regulation Of Microtubule Polymerization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Postsynapse Cell Junction Organization Cell Projection Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Or Depolymerization Actin Filament Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Lamellipodium Organization Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Plasma Membrane Bounded Cell Projection Assembly Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Substrate Adhesion-dependent Cell Spreading Cell-cell Junction Endocytosis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Signal Complex Assembly Intracellular Signaling Cassette Presynapse Thioesterase Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Regulation Of Neurotransmitter Secretion Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Stress Fiber Assembly
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