GIT2 and PROX1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GIT2	PROX1
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 2	prospero homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Nucleus Cytoplasm
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Transcription Regulatory Region DNA Binding DBD Domain Binding LBD Domain Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Behavioral Response To Pain	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Determination Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Lens Development In Camera-type Eye Hepatocyte Cell Migration Transcription From RNA Polymerase II Promoter Brain Development Circadian Rhythm Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Optic Placode Formation Involved In Camera-type Eye Formation Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Maintenance Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation
Pathways
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148) Metabolite levels (MHPG) ( 23319000)	Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HIV-1 progression ( 20064070) Obesity ( 23818313)
Protein-Protein Interactions		44 interactors: ACTG1 ACTN1 ADRBK1 ARHGEF7 ATF5 C4BPA CALCOCO2 CORO1A E2F2 EDC4 GCH1 GIT1 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	17 interactors: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3
Entrez ID		9815	5629
HPRD ID		09779	03330
Ensembl ID		ENSG00000139436	ENSG00000117707
Uniprot IDs		F8VXI9 Q14161 Q6FI58	Q92786
PDB IDs			2LMD
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Ephrin Receptor Signaling Pathway Innate Immune Response Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of Immune System Process Cell Death Regulation Of Metabolic Process Death Positive Regulation Of Immune Response Defense Response Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Adherens Junction Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Focal Adhesion Assembly Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Signaling Regulation Of Kinase Activity Cellular Component Assembly Cell Communication Regulation Of Phosphorylation Adherens Junction Assembly Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Development Cell-substrate Junction Assembly Activation Of MAPK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Stress Activation Of Innate Immune Response Cell Surface Receptor Signaling Pathway	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Cellular Response To Lipid Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Lipid Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Hormone Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Organic Substance Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Signal Transduction Involved In Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Response To Hypoxia Signal Transduction
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole
Tagcloud (Intersection) ?