GIT1 and HMOX2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		GIT1	HMOX2
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 1	heme oxygenase (decycling) 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome	Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding
	Biological Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport
Pathways		Ephrin signaling Axon guidance EPH-Ephrin signaling	Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746
Entrez ID		28964	3163
HPRD ID		06577	00783
Ensembl ID		ENSG00000108262	ENSG00000103415
Uniprot IDs		Q59FC3 Q9Y2X7	I3L430 P30519
PDB IDs			2Q32 2QPP 2RGZ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation	Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Intersection) ?