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GIT2 and GCH1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
GIT2
GCH1
Description
GIT ArfGAP 2
GTP cyclohydrolase 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Focal Adhesion
Synapse
Presynapse
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasmic Vesicle
Nuclear Membrane
Protein-containing Complex
Neuron Projection Terminus
Molecular Function
GTPase Activator Activity
Protein Binding
Zinc Ion Binding
Small GTPase Binding
Metal Ion Binding
Nucleotide Binding
Catalytic Activity
GTPase Activity
GTP Cyclohydrolase I Activity
Protein Binding
GTP Binding
Zinc Ion Binding
Hydrolase Activity
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Mitogen-activated Protein Kinase Binding
Biological Process
Brain Development
Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of ARF Protein Signal Transduction
Synaptic Vesicle Recycling
Tetrahydrobiopterin Biosynthetic Process
Nitric Oxide Biosynthetic Process
Regulation Of Blood Pressure
Positive Regulation Of Heart Rate
Regulation Of Lung Blood Pressure
Response To Lipopolysaccharide
Response To Type II Interferon
Response To Tumor Necrosis Factor
Dopamine Biosynthetic Process
Pteridine-containing Compound Metabolic Process
Pteridine-containing Compound Biosynthetic Process
Tetrahydrobiopterin Metabolic Process
Tetrahydrofolate Biosynthetic Process
Response To Pain
Neuromuscular Process Controlling Posture
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Removal Of Superoxide Radicals
Pathways
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs
Guanine
Diseases
Primary torsion dystonia (PTD)
Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS
Bipolar disorder (
31043756
)
Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia (
28922980
)
Metabolic syndrome (
20694148
)
Metabolite levels (
23823483
)
Metabolite levels (MHPG) (
23319000
)
Chronotype (
30696823
)
Mercury levels (
26025379
)
Night sleep phenotypes (
27126917
)
Obesity-related traits (
23251661
)
Parkinson's disease (
25064009
27182965
28892059
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Rheumatoid arthritis (
22446963
)
Serum metabolite levels (
33031748
)
Interacting Genes
47 interacting genes:
ACTG1
ACTN1
ARHGEF7
ATF5
C4BPA
CALCOCO2
CDC42
CORO1A
E2F2
EDC4
GCH1
GET4
GIT1
GRK2
GUSB
HGD
HNRNPUL1
IKBKG
KCTD5
KRT18
LAMTOR5
LMNB1
MVP
NFKBIB
NME2
PAK1
PAK3
PCLO
POLR1B
PROX1
PXN
QPRT
RCVRN
RUFY1
RUSC2
SAFB2
SH3GLB2
SMAD3
SPOP
TGFB1I1
TNFAIP3
TNIP1
TRAF1
TSN
UBQLN1
USHBP1
YWHAG
15 interacting genes:
AHSA1
ATP1B1
CDC37
CNRIP1
GCHFR
GIT2
HSPA8
RAB26
RLF
RPH3A
SH3GL2
SP3
TNPO2
TNPO3
YWHAZ
Entrez ID
9815
2643
HPRD ID
09779
02573
Ensembl ID
ENSG00000139436
ENSG00000131979
Uniprot IDs
F8VXI9
F8W822
Q14161
Q6FI58
P30793
Q8IZH9
PDB IDs
1FB1
6Z80
6Z85
6Z86
6Z87
6Z88
6Z89
7ALA
7ALB
7ALC
7ALQ
Enriched GO Terms of Interacting Partners
?
Identical Protein Binding
Cytosol
Regulation Of Supramolecular Fiber Organization
Cytoplasm
Focal Adhesion
Regulation Of Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Organization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament-based Process
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Cytoskeleton Organization
Lamellipodium
Ephrin Receptor Signaling Pathway
Cell-cell Junction
Regulation Of Microtubule Nucleation
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Organization
Regulation Of Lung Blood Pressure
Actin Cytoskeleton Organization
Regulation Of Signal Transduction
Actin Filament
Cytoskeleton
Gamma-tubulin Binding
Actin Filament-based Process
Response To Type II Interferon
Regulation Of Intracellular Signal Transduction
Ruffle
Positive Regulation Of Microtubule Nucleation
Regulation Of Canonical NF-kappaB Signal Transduction
Postsynapse Organization
Extracellular Exosome
Cytoskeleton Organization
Regulation Of Organelle Organization
Profilin Binding
Signal Transduction
Thioesterase Binding
Neuron Fate Determination
Regulation Of Apoptotic Process
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Organelle Organization
Vinculin Binding
Regulation Of Programmed Cell Death
Ameboidal-type Cell Migration
Regulation Of Toll-like Receptor 3 Signaling Pathway
Cell Surface Receptor Signaling Pathway
Immunological Synapse Formation
Establishment Of Localization In Cell
GMP Binding
Regulation Of Protein Stability
Establishment Of Protein Localization
Cellular Localization
Extrinsic Component Of Synaptic Vesicle Membrane
Protein Targeting
Protein Kinase Binding
ATPase Activator Activity
Intracellular Protein Localization
MHC Class II Protein Complex Binding
Protein Transport
Melanosome
Protein-folding Chaperone Binding
Unfolded Protein Binding
Small GTPase Binding
Nuclear Import Signal Receptor Activity
Import Into Nucleus
Intracellular Protein Transport
Protein Folding Chaperone Complex
Intracellular Transport
GTP Cyclohydrolase I Regulator Activity
GTP Cyclohydrolase Binding
Chaperone-mediated Autophagy Translocation Complex Disassembly
Establishment Of Protein Localization To Organelle
Exocrine System Development
Type 1 Cannabinoid Receptor Binding
ATP Metabolic Process
Hsp90 Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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