GIT2 and PCLO

Number of citations of the paper that reports this interaction (PMID 12473661)
21

Data Source:
BioGRID (two hybrid)

		GIT2	PCLO
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 2	piccolo presynaptic cytomatrix protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Cytoskeleton Synaptic Vesicle Postsynaptic Density Membrane Cell Junction Synapse Presynaptic Cytoskeletal Matrix Assembled At Active Zones Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Transporter Activity Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Behavioral Response To Pain	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion
Pathways
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148) Metabolite levels (MHPG) ( 23319000)	Major depressive disorder ( 21621269)
Protein-Protein Interactions		44 interactors: ACTG1 ACTN1 ADRBK1 ARHGEF7 ATF5 C4BPA CALCOCO2 CORO1A E2F2 EDC4 GCH1 GIT1 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	3 interactors: ERC2 GIT1 GIT2
Entrez ID		9815	27445
HPRD ID		09779	16078
Ensembl ID		ENSG00000139436	ENSG00000186472
Uniprot IDs		F8VXI9 Q14161 Q6FI58	Q9Y6V0
PDB IDs			1UJD
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Ephrin Receptor Signaling Pathway Innate Immune Response Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of Immune System Process Cell Death Regulation Of Metabolic Process Death Positive Regulation Of Immune Response Defense Response Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Adherens Junction Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Focal Adhesion Assembly Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Signaling Regulation Of Kinase Activity Cellular Component Assembly Cell Communication Regulation Of Phosphorylation Adherens Junction Assembly Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Development Cell-substrate Junction Assembly Activation Of MAPK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Stress Activation Of Innate Immune Response Cell Surface Receptor Signaling Pathway	Regulation Of ARF GTPase Activity Regulation Of ARF Protein Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Behavioral Response To Pain Positive Regulation Of Hydrolase Activity Response To Pain Positive Regulation Of Catalytic Activity Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Multicellular Organismal Response To Stress Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Intersection) ?