GIT2 and GUSB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GIT2	GUSB
Description		GIT ArfGAP 2	glucuronidase beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion Synapse Presynapse	Extracellular Region Extracellular Space Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucuronidase Activity Signaling Receptor Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Domain Specific Binding Carbohydrate Binding
	Biological Process	Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Synaptic Vesicle Recycling	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Chondroitin Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	CS/DS degradation Hyaluronan degradation MPS VII - Sly syndrome (Hyaluronan metabolism) Neutrophil degranulation MPS VII - Sly syndrome (CS/DS degradation)
Drugs
Diseases			Mucopolysaccharidosis type VII (MPS7); Sly syndrome
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		47 interacting genes: ACTG1 ACTN1 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	3 interacting genes: CES1 GIT2 PRKACA
Entrez ID		9815	2990
HPRD ID		09779	02018
Ensembl ID		ENSG00000139436	ENSG00000169919
Uniprot IDs		F8VXI9 F8W822 Q14161 Q6FI58	P08236
PDB IDs			1BHG 3HN3
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytosol Regulation Of Supramolecular Fiber Organization Cytoplasm Focal Adhesion Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Ephrin Receptor Signaling Pathway Cell-cell Junction Regulation Of Microtubule Nucleation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Organization Regulation Of Lung Blood Pressure Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament Cytoskeleton Gamma-tubulin Binding Actin Filament-based Process Response To Type II Interferon Regulation Of Intracellular Signal Transduction Ruffle Positive Regulation Of Microtubule Nucleation Regulation Of Canonical NF-kappaB Signal Transduction Postsynapse Organization Extracellular Exosome Cytoskeleton Organization Regulation Of Organelle Organization Profilin Binding Signal Transduction Thioesterase Binding Neuron Fate Determination Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Organelle Organization Vinculin Binding Regulation Of Programmed Cell Death Ameboidal-type Cell Migration Regulation Of Toll-like Receptor 3 Signaling Pathway Cell Surface Receptor Signaling Pathway Immunological Synapse Formation	Regulation Of Cholesterol Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process Positive Regulation Of Lipid Metabolic Process Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Small Molecule Metabolic Process Regulation Of Lipid Biosynthetic Process Methylumbelliferyl-acetate Deacetylase Activity Regulation Of Bile Acid Secretion Carboxylesterase Activity Sterol Ester Esterase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process CAMP-dependent Protein Kinase Activity Regulation Of Bile Acid Biosynthetic Process Regulation Of Bile Acid Metabolic Process Medium-chain Fatty Acid Metabolic Process Negative Regulation Of Cholesterol Storage CAMP-dependent Protein Kinase Complex Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Interleukin-2-mediated Signaling Pathway Cellular Response To Epinephrine Stimulus Cellular Response To Sterol Negative Regulation Of Lipid Storage Regulation Of Secretion Reverse Cholesterol Transport Cellular Response To Cholesterol Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Glycolytic Process Response To Laminar Fluid Shear Stress Sperm Capacitation Cellular Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Cholesterol Biosynthetic Process Cell Communication By Electrical Coupling Renal Water Homeostasis Response To Parathyroid Hormone Positive Regulation Of Gluconeogenesis
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