GIT1 and PPFIA2

Number of citations: 56 (PubMedID 12629171)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		GIT1	PPFIA2
Name		GIT ArfGAP 1	PPFI scaffold protein A2
Structure		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Synaptic Vesicle Cell Surface Postsynaptic Density Axon Presynaptic Membrane Cell Projection Dendritic Spine Synapse Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding	Protein Binding Structural Constituent Of Postsynaptic Density Structural Constituent Of Presynapse
	Biological Process	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process	Cell-matrix Adhesion Synapse Organization Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Presynapse Organization Dense Core Granule Cytoskeletal Transport Maintenance Of Postsynaptic Density Structure Regulation Of Synaptic Vesicle Exocytosis
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
GWAS		Adult body size ( 32376654 ) Brain morphology (MOSTest) ( 32665545 )	Age-related cataracts (age at onset) ( 25352737 ) Alcohol dependence ( 26365420 ) Delirium ( 29631748 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Lean body mass ( 28552196 ) Post bronchodilator FEV1 ( 26634245 ) Resting heart rate ( 27798624 ) Schizophrenia ( 22885689 )
Novel Interactors		2 novel interactors: B9D1 GPAA1	1 novel interactors: IPO13
Interacting Genes		54 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	15 interacting genes: CAST CDC5L ERC2 GIT1 ITSN1 MTDH PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS SMARCA2 TSC1
Entrez ID		28964	8499
HPRD ID		06577	04392
Ensembl ID		ENSG00000108262	ENSG00000139220
Uniprot IDs		Q59FC3 Q9Y2X7	B7Z7Y5 G3V200 H0YHK3 O75334
PDB IDs		Not available	3TAC 3TAD 6IUH 7D2E 7D2G 7D2H
GO Terms Enriched among Interactors		Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization	Synapse Organization Presynaptic Active Zone Cell Junction Organization Synaptic Membrane Adhesion Presynaptic Membrane Glutamatergic Synapse Regulation Of Dendritic Spine Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Cortical Microtubule Organization Presynaptic Active Zone Organization Regulation Of Organelle Organization Presynaptic Active Zone Cytoplasmic Component Schaffer Collateral - CA1 Synapse Protein Tyrosine Phosphatase Activity Regulation Of Postsynaptic Density Assembly Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cellular Component Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Neuron Projection Regulation Of Postsynapse Organization Phosphoprotein Phosphatase Activity Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Maintenance Of Synapse Structure Regulation Of Response To Wounding Neuromuscular Junction Development Cell Cortex Positive Regulation Of Dendritic Spine Development Lamellipodium Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Modulation Of Chemical Synaptic Transmission Chondroitin Sulfate Proteoglycan Binding Memory T Cell Differentiation Cortical Cytoskeleton Organization Epididymosome Negative Regulation Of ARF Protein Signal Transduction Cell Junction Maintenance Synapse Presynapse Nervous System Development Postsynaptic Density Cytoplasmic Microtubule Organization Regulation Of Cell Junction Assembly Clathrin-dependent Synaptic Vesicle Endocytosis Cellular Component Maintenance