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GIT1 and PPFIA2
Number of citations of the paper that reports this interaction (PubMedID
12629171
)
56
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
GIT1
PPFIA2
Description
GIT ArfGAP 1
PPFI scaffold protein A2
Image
No pdb structure
GO Annotations
Cellular Component
Spindle Pole
Cytoplasm
Mitochondrion
Endosome
Centrosome
Cytosol
Cytoskeleton
Focal Adhesion
Postsynaptic Density
Membrane
Lamellipodium
Dendrite
Growth Cone
Cell Projection
Neuron Projection
Calyx Of Held
Synapse
Excitatory Synapse
Inhibitory Synapse
Anchoring Junction
Mitotic Spindle Pole
Presynapse
Postsynapse
Glutamatergic Synapse
GABA-ergic Synapse
Cytoplasm
Cytosol
Synaptic Vesicle
Cell Surface
Postsynaptic Density
Axon
Presynaptic Membrane
Cell Projection
Dendritic Spine
Synapse
Presynaptic Active Zone
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization
Molecular Function
GTPase Activator Activity
Protein Binding
Zinc Ion Binding
Protein Phosphatase Binding
Small GTPase Binding
Identical Protein Binding
Gamma-tubulin Binding
Protein-containing Complex Binding
Metal Ion Binding
Scaffold Protein Binding
Structural Constituent Of Postsynaptic Specialization
Protein Tyrosine Kinase Binding
Protein Binding
Structural Constituent Of Postsynaptic Density
Structural Constituent Of Presynapse
Biological Process
Immunological Synapse Formation
Intramembranous Ossification
Brain Development
Locomotory Behavior
Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of ARF Protein Signal Transduction
Negative Regulation Of ARF Protein Signal Transduction
Regulation Of Cytokinesis
Negative Regulation Of Interleukin-1 Beta Production
Synaptic Vesicle Recycling
Cell Redox Homeostasis
Negative Regulation Of Glycolytic Process
Ephrin Receptor Signaling Pathway
Neuron Development
Dendritic Spine Development
Motor Learning
Cellular Response To Lipopolysaccharide
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Microtubule Nucleation
Maintenance Of Postsynaptic Specialization Structure
Presynaptic Modulation Of Chemical Synaptic Transmission
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Negative Regulation Of Inflammatory Response To Wounding
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Receptor Catabolic Process
Cell-matrix Adhesion
Synapse Organization
Regulation Of Dendritic Spine Development
Regulation Of Dendritic Spine Morphogenesis
Presynapse Organization
Dense Core Granule Cytoskeletal Transport
Maintenance Of Postsynaptic Density Structure
Regulation Of Synaptic Vesicle Exocytosis
Pathways
Ephrin signaling
Ephrin signaling
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Activation of RAC1 downstream of NMDARs
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Age-related cataracts (age at onset) (
25352737
)
Alcohol dependence (
26365420
)
Delirium (
29631748
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Lean body mass (
28552196
)
Post bronchodilator FEV1 (
26634245
)
Resting heart rate (
27798624
)
Schizophrenia (
22885689
)
Interacting Genes
54 interacting genes:
ARHGEF6
ARHGEF7
BARD1
C8orf33
CENPU
CEP126
CFAP263
CHD3
DDX24
DSCR9
EIF6
ENTR1
GIT2
GRB2
GRK2
GRK3
GRK5
GRK6
HAP1
HMOX2
HSPA13
HTT
KIF1A
KLHL4
LAMTOR5
LPXN
LRIF1
MAN2A2
NEK2
PAK3
PCLO
PDPK1
PFDN1
PLCG1
PMF1
PPFIA1
PPFIA2
PPFIA3
PPFIA4
PTK2
PTPRZ1
PXN
RAN
RGS2
RIF1
SRC
SRRT
TAB1
TERF1
TGFB1I1
TRIB3
TXNDC9
WDR33
YWHAG
15 interacting genes:
CAST
CDC5L
ERC2
GIT1
ITSN1
MTDH
PPFIA1
PPFIA3
PPFIBP1
PPFIBP2
PTPRD
PTPRF
PTPRS
SMARCA2
TSC1
Entrez ID
28964
8499
HPRD ID
06577
04392
Ensembl ID
ENSG00000108262
ENSG00000139220
Uniprot IDs
Q59FC3
Q9Y2X7
B7Z7Y5
G3V200
H0YHK3
O75334
PDB IDs
3TAC
3TAD
6IUH
7D2E
7D2G
7D2H
Enriched GO Terms of Interacting Partners
?
Beta-adrenergic Receptor Kinase Activity
G Protein-coupled Receptor Kinase Activity
Cytoplasm
Presynaptic Active Zone
Focal Adhesion
Cell Projection
Epidermal Growth Factor Receptor Signaling Pathway
Signal Complex Assembly
Cytoskeleton
Cytosol
ERBB Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Synapse
Centrosome
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Regulation Of G Protein-coupled Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Organelle Localization
Transforming Growth Factor Beta Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Kinase Activity
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Kinase Activity
Vesicle Cytoskeletal Trafficking
Positive Regulation Of Calcium Ion Transmembrane Transport
Vesicle Localization
Protein Autophosphorylation
Centriolar Satellite
ATP Binding
Cell Junction Organization
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cell-substrate Adhesion
Protein-containing Complex
Cellular Response To Fluid Shear Stress
Synapse Organization
Positive Regulation Of Cilium Assembly
Negative Adaptation Of Signaling Pathway
Positive Regulation Of Lamellipodium Morphogenesis
Establishment Of Organelle Localization
Positive Regulation Of Organelle Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Protein Phosphatase Binding
Tachykinin Receptor Signaling Pathway
Regulation Of Cell Communication
Protein Serine/threonine Kinase Activity
Regulation Of Signaling
Regulation Of Cell Projection Organization
Synapse Organization
Presynaptic Active Zone
Cell Junction Organization
Synaptic Membrane Adhesion
Presynaptic Membrane
Glutamatergic Synapse
Regulation Of Dendritic Spine Development
Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway
Cortical Microtubule Organization
Presynaptic Active Zone Organization
Regulation Of Organelle Organization
Presynaptic Active Zone Cytoplasmic Component
Schaffer Collateral - CA1 Synapse
Protein Tyrosine Phosphatase Activity
Regulation Of Postsynaptic Density Assembly
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Regulation Of Cellular Component Organization
Regulation Of Postsynaptic Specialization Assembly
Regulation Of Excitatory Synapse Assembly
Peptidyl-tyrosine Dephosphorylation
Neuron Projection
Regulation Of Postsynapse Organization
Phosphoprotein Phosphatase Activity
Regulation Of Axon Regeneration
Growth Cone
Regulation Of Neuron Projection Regeneration
Maintenance Of Synapse Structure
Regulation Of Response To Wounding
Neuromuscular Junction Development
Cell Cortex
Positive Regulation Of Dendritic Spine Development
Lamellipodium
Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Modulation Of Chemical Synaptic Transmission
Chondroitin Sulfate Proteoglycan Binding
Memory T Cell Differentiation
Cortical Cytoskeleton Organization
Epididymosome
Negative Regulation Of ARF Protein Signal Transduction
Cell Junction Maintenance
Synapse
Presynapse
Nervous System Development
Postsynaptic Density
Cytoplasmic Microtubule Organization
Regulation Of Cell Junction Assembly
Clathrin-dependent Synaptic Vesicle Endocytosis
Cellular Component Maintenance
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