GIT1 and PPFIA4

Number of citations of the paper that reports this interaction (PubMedID 12629171)
56

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		GIT1	PPFIA4
Description		GIT ArfGAP 1	PPFI scaffold protein A4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Cell Surface Synapse Presynaptic Active Zone
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding	Protein Binding
	Biological Process	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process	Synapse Organization
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 28416822 29892015 30061737) Early onset atrial fibrillation ( 28460022)
Interacting Genes		54 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	6 interacting genes: AGTPBP1 CAST DNAJC5 ERC2 GIT1 NCOA2
Entrez ID		28964	8497
HPRD ID		06577	16012
Ensembl ID		ENSG00000108262	ENSG00000143847
Uniprot IDs		Q59FC3 Q9Y2X7	A0A8J8YUZ5 B3KN22 B4DIS5 O75335
PDB IDs
Enriched GO Terms of Interacting Partners?		Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization	Presynaptic Active Zone Organization Locomotory Behavior Maintenance Of Synapse Structure Presynapse Cell Junction Maintenance Cellular Component Maintenance Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of ARF Protein Signal Transduction Anterograde Axonal Transport Of Mitochondrion GABA-ergic Synapse Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Vesicle-mediated Transport Structural Constituent Of Postsynaptic Specialization Cellular Response To Thyroglobulin Triiodothyronine Retrograde Axonal Transport Of Mitochondrion C-terminal Protein Deglutamylation Growth Cone Protein Deglutamylation Protein Side Chain Deglutamylation Neuron Development Response To Thyroglobulin Triiodothyronine Negative Regulation Of Type B Pancreatic Cell Apoptotic Process RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Aryl Hydrocarbon Receptor Binding Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Intramembranous Ossification Positive Regulation Of Microtubule Nucleation Motor Learning ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Synapse Organization Positive Regulation Of Receptor Catabolic Process Maintenance Of Postsynaptic Specialization Structure Negative Regulation Of Inflammatory Response To Wounding Cytoplasm Locomotor Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Adipose Tissue Development Peptidyl-glutamic Acid Modification Cerebellar Purkinje Cell Layer Development Axonal Transport Of Mitochondrion Cerebellar Purkinje Cell Differentiation Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Presynaptic Active Zone Cytoplasmic Component Immunological Synapse Formation Dendritic Spine Development Regulation Of Inflammatory Response To Wounding
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