GIT1 and PCLO

Number of citations of the paper that reports this interaction (PMID 12473661)
21

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		GIT1	PCLO
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 1	piccolo presynaptic cytomatrix protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome	Cytoskeleton Synaptic Vesicle Postsynaptic Density Membrane Cell Junction Synapse Presynaptic Cytoskeletal Matrix Assembled At Active Zones Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Transporter Activity Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding
	Biological Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion
Pathways		Ephrin signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Major depressive disorder ( 21621269)
Protein-Protein Interactions		50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	3 interactors: ERC2 GIT1 GIT2
Entrez ID		28964	27445
HPRD ID		06577	16078
Ensembl ID		ENSG00000108262	ENSG00000186472
Uniprot IDs		Q59FC3 Q9Y2X7	Q9Y6V0
PDB IDs			1UJD
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation	Regulation Of ARF GTPase Activity Regulation Of ARF Protein Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Behavioral Response To Pain Positive Regulation Of Hydrolase Activity Response To Pain Positive Regulation Of Catalytic Activity Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Multicellular Organismal Response To Stress Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Intersection) ?