MDC1 and COPS5

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		MDC1	COPS5
Description		mediator of DNA damage checkpoint 1	COP9 signalosome subunit 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body Site Of Double-strand Break	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Chromatin-protein Adaptor Activity Histone Reader Activity	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Protein K6-linked Ubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Eosinophil count ( 31272903)
Interacting Genes		42 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 USP7 VAMP5 WRN ZNF251	113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG
Entrez ID		9656	10987
HPRD ID		16252	06888
Ensembl ID		ENSG00000137337	ENSG00000121022
Uniprot IDs		A0A1U9XBC1 A0A1U9XBE3 A0A1U9XBF2 A1Z5I9 Q14676	A0A024R7W9 Q92905
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT 9IF9	4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of DNA Repair Response To Ionizing Radiation Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress DNA Damage Checkpoint Signaling Post-translational Protein Modification Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Nucleic Acid Metabolic Process Regulation Of DNA Recombination Nucleus Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Phase Transition Chromatin Remodeling PML Body Macromolecule Metabolic Process Protein Modification Process Chromatin Organization Cellular Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Macromolecule Metabolic Process Response To Stress Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Recombinational Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Regulation Of Primary Metabolic Process Homologous Recombination Ubiquitin-modified Histone Reader Activity Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation Positive Regulation Of DNA Recombination	Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?