COPS5 and CUL1

Number of citations of the paper that reports this interaction (PubMedID 37028429)
81

Data Source:
BioGRID (enzymatic study)

		COPS5	CUL1
Description		COP9 signalosome subunit 5	cullin 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Lysosome Organization Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Oxidative Stress TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins
Drugs
Diseases
GWAS			Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)
Interacting Genes		113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG	62 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CEBPA CENPE CENPW CFLAR CFTR CHEK1 CHUK CKS1B COMMD1 COPS5 COPS6 COPS8 DLEU2 DVL2 E2F1 EIF4ENIF1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 FBXW8 GHR GPS1 HIPK2 HOOK1 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1
Entrez ID		10987	8454
HPRD ID		06888	04389
Ensembl ID		ENSG00000121022	ENSG00000055130
Uniprot IDs		A0A024R7W9 Q92905	A0A090N7U0 B3KTW0 Q13616
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89 6TTU 6WCQ 7B5L 7B5M 7B5N 7B5R 7B5S 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CAF 8CDJ 8CDK 8OR0 8OR2 8OR3 8OR4 8UA6 8UBT 8UBU 8VVY 9JKB 9KBD
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex	Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification Process Protein Metabolic Process Protein Neddylation Macromolecule Metabolic Process Cytosol Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Nucleus Nucleoplasm Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Deneddylation Macromolecule Catabolic Process NEDD8 Transferase Activity Protein K48-linked Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Polyubiquitination Cytoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Intracellular Signal Transduction Cul7-RING Ubiquitin Ligase Complex NEDD8 Ligase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Protein Monoubiquitination Ubiquitin-like Ligase-substrate Adaptor Activity Cullin Family Protein Binding Positive Regulation Of Signal Transduction Protein Destabilization Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process
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