COPS5 and SREBF2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		COPS5	SREBF2
Description		COP9 signalosome subunit 5	sterol regulatory element binding transcription factor 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle SREBP-SCAP-Insig Complex
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity	C-8 Sterol Isomerase Activity Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Negative Regulation Of Amyloid-beta Clearance Regulation Of Mitophagy Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 27680694 31043758) Caffeine consumption from tea ( 33287642) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG	50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX
Entrez ID		10987	6721
HPRD ID		06888	02726
Ensembl ID		ENSG00000121022	ENSG00000198911
Uniprot IDs		A0A024R7W9 Q92905	Q12772
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	1UKL
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex	Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Steroid Metabolic Process Regulation Of Signal Transduction Enzyme Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Cholesterol Metabolic Process SUMO Transferase Activity Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Protein Sumoylation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Metabolic Process Rhythmic Process PML Body Transcription Cis-regulatory Region Binding Regulation Of Intracellular Transport Regulation Of Protein Stability Regulation Of Lipid Biosynthetic Process Presynaptic Cytosol Negative Regulation Of RNA Metabolic Process
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