MDC1 and CENPC

Number of citations: 0 (PubMedID 14578343)
Data Source: BioGRID (unspecified method)

		MDC1	CENPC
Name		mediator of DNA damage checkpoint 1	centromere protein C
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body Site Of Double-strand Break	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol Nuclear Body Midbody
	Molecular Function	Protein Binding Chromatin-protein Adaptor Activity Histone Reader Activity	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Protein K6-linked Ubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Mitotic Cell Cycle Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Spindle Attachment To Meiosis I Kinetochore
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Eosinophil count ( 31272903 )	Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Walking pace ( 33128006 )
Interacting Genes		42 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 USP7 VAMP5 WRN ZNF251	8 interacting genes: CIP2A DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF
Entrez ID		9656	1060
HPRD ID		16252	00315
Ensembl ID		ENSG00000137337	ENSG00000145241
Uniprot IDs		A0A1U9XBC1 A0A1U9XBE3 A0A1U9XBF2 A1Z5I9 Q14676	Q03188
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT 9IF9	5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF 7PII 7QOO 7R5R 7XHN 7XHO 7YWX 7YYH
GO Terms Enriched among Interactors		DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of DNA Repair Response To Ionizing Radiation Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress DNA Damage Checkpoint Signaling Post-translational Protein Modification Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Nucleic Acid Metabolic Process Regulation Of DNA Recombination Nucleus Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Phase Transition Chromatin Remodeling PML Body Macromolecule Metabolic Process Protein Modification Process Chromatin Organization Cellular Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Macromolecule Metabolic Process Response To Stress Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Recombinational Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Regulation Of Primary Metabolic Process Homologous Recombination Ubiquitin-modified Histone Reader Activity Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation Positive Regulation Of DNA Recombination	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide DNA-templated Transcription Initiation RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Broken Chromosome Clustering PML Body Regulation Of RNA Metabolic Process Regulation Of Synaptic Membrane Adhesion Regulation Of Macromolecule Metabolic Process Target-directed MiRNA Degradation Elongin Complex Regulation Of Glucose Mediated Signaling Pathway Signal Transduction In Response To DNA Damage Cellular Response To Sodium Arsenite RNA Polymerase I General Transcription Initiation Factor Activity Nucleoplasm NFAT Protein Binding Response To Sodium Arsenite Cellular Response To Salt Mitogen-activated Protein Kinase P38 Binding Regulation Of Metabolic Process Stress-induced Premature Senescence Protein-DNA Complex Assembly Chromosome Protein Modification By Small Protein Conjugation Cellular Response To Stress NLRP1 Inflammasome Complex Assembly Transcription Initiation At RNA Polymerase I Promoter Protein Modification Process RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition RNA Polymerase I Preinitiation Complex Assembly