MDC1 and HDAC8

Number of citations of the paper that reports this interaction (PMID 14578343)
66

Data Source:
BioGRID (unspecified method)

		MDC1	HDAC8
Gene Name		mediator of DNA-damage checkpoint 1	histone deacetylase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Intra-S DNA Damage Checkpoint	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Sister Chromatid Cohesion Chromatin Modification Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Cohesin Localization To Chromatin
Pathways		ATM mediated phosphorylation of repair proteins ATM mediated response to DNA double-strand break Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs			Vorinostat 4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4\'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4\'-HYDROXYAMIDE 7-AMINO-4-METHYL-CHROMEN-2-ONE
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251	9 interactors: ESRRA HIST1H3A HIST1H4A HIST3H3 HIST4H4 MDC1 PRKACA RTN1 RUNX1T1
Entrez ID		9656	55869
HPRD ID		16252	02227
Ensembl ID		ENSG00000137337	ENSG00000147099
Uniprot IDs		A1Z5I9 Q14676	Q9BY41
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT	1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cell Cycle Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process Response To Ionizing Radiation Positive Regulation Of Metabolic Process Chromosome Organization Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Response To Radiation Regulation Of Metabolic Process DNA Recombination Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Abiotic Stimulus Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Protein Modification Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Nucleosome Assembly Chromatin Assembly Chromosome Organization Nucleosome Organization DNA Metabolic Process Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Megakaryocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging CENP-A Containing Nucleosome Assembly Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Chromatin Organization Protein Demethylation Mitotic Cell Cycle DNA Conformation Change Centromere Complex Assembly Nucleobase-containing Compound Metabolic Process Demethylation ATP-dependent Chromatin Remodeling Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Positive Regulation Of Dense Core Granule Biogenesis Methylation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein
Tagcloud (Difference) ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein
Tagcloud (Intersection) ?