COPS5 and MIF

Number of citations of the paper that reports this interaction (PMID 11089976)
93

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		COPS5	MIF
Gene Name		COP9 signalosome subunit 5	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cell Surface Vesicle Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Dopachrome Isomerase Activity Receptor Binding Cytokine Activity Cytokine Receptor Binding Protein Binding Chemoattractant Activity Phenylpyruvate Tautomerase Activity
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Prostaglandin Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Cell Aging Cell Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cell Aging Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Drugs			3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester Citric Acid 3-(4-HYDROXY-PHENYL)PYRUVIC ACID 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	12 interactors: BNIPL CD74 COPS5 COPS6 GORASP2 NGFRAP1 NME1 STRN4 TP53 UPF2 WDYHV1 ZNF408
Entrez ID		10987	4282
HPRD ID		06888	01091
Ensembl ID		ENSG00000121022
Uniprot IDs		Q92905	I4AY87 P14174
PDB IDs		4F7O	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Cullin Deneddylation Protein Deneddylation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Lymphocyte Apoptotic Process T Cell Differentiation In Thymus Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Regulation Of Fibroblast Proliferation
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	analyzing anterior antiparasitic antiserum autocrine blocked completely counter deactivating demonstrating dihydrochloride endogenously exhibits glucocorticoid hypersensitivity iminoethyl inos kill knockout leishmania mab macrophage macrophages n6 nodes pituitary proinflammatory requirement tnf
Tagcloud (Intersection) ?