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MDC1 and NSD2
Number of citations of the paper that reports this interaction (PubMedID
31248990
)
56
Data Source:
BioGRID
(proximity labelling technology, unspecified method)
MDC1
NSD2
Description
mediator of DNA damage checkpoint 1
nuclear receptor binding SET domain protein 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Focal Adhesion
Nuclear Body
Site Of Double-strand Break
Chromatin
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Molecular Function
Protein Binding
Chromatin-protein Adaptor Activity
Histone Reader Activity
DNA Binding
Chromatin Binding
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Histone Methyltransferase Activity
Histone H4K20 Methyltransferase Activity
Sequence-specific DNA Binding
Metal Ion Binding
Histone H3K36 Methyltransferase Activity
Histone H3 Methyltransferase Activity
Histone H3K36 Dimethyltransferase Activity
Histone H3K36 Trimethyltransferase Activity
Biological Process
DNA Replication Checkpoint Signaling
DNA Repair
Chromatin Organization
DNA Damage Response
Mitotic Intra-S DNA Damage Checkpoint Signaling
Protein K6-linked Ubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Transcription By RNA Polymerase II
Membranous Septum Morphogenesis
Atrial Septum Primum Morphogenesis
Atrial Septum Secundum Morphogenesis
Double-strand Break Repair
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Methylation
Positive Regulation Of Isotype Switching To IgA Isotypes
Bone Development
Regulation Of Establishment Of Protein Localization
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
TP53 Regulates Transcription of DNA Repair Genes
G2/M DNA damage checkpoint
PKMTs methylate histone lysines
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
Multiple myeloma
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Eosinophil count (
31272903
)
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Interacting Genes
42 interacting genes:
ANAPC1
ATM
BARD1
BDKRB1
BRCA1
CASP3
CENPC
CHEK2
COPS5
CREBBP
CSNK2A1
DTX2
EP300
GATA4
H2AX
HDAC10
HDAC8
HINFP
NBN
NCL
NSD2
PIAS1
PIAS4
PRIM1
PTEN
RAD50
RAD51
RNF8
SMC1A
SRPK2
SUMO2
TNKS2
TP53
TP53BP1
UIMC1
USP13
USP15
USP28
USP7
VAMP5
WRN
ZNF251
15 interacting genes:
AGO2
APP
AR
AURKA
BRCA1
ESR1
H19
H3-4
H3C1
H3C14
HORMAD2
MDC1
PCNA
PLEKHF2
TP53
Entrez ID
9656
7468
HPRD ID
16252
04259
Ensembl ID
ENSG00000137337
ENSG00000109685
Uniprot IDs
A0A1U9XBC1
A0A1U9XBE3
A0A1U9XBF2
A1Z5I9
Q14676
O96028
PDB IDs
2ADO
2AZM
2ETX
3K05
3UEO
3UMZ
3UN0
3UNM
3UNN
3UOT
9IF9
5LSU
5VC8
6UE6
6XCG
7CRO
7E8D
7LMT
7MDN
7VLN
9EXW
9EXX
9EXY
9GBF
Enriched GO Terms of Interacting Partners
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DNA Repair
DNA Damage Response
DNA Metabolic Process
Double-strand Break Repair
Regulation Of Cellular Response To Stress
Nucleoplasm
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Response To Ionizing Radiation
Response To Radiation
Negative Regulation Of Cell Cycle Phase Transition
Cellular Response To Stress
DNA Damage Checkpoint Signaling
Post-translational Protein Modification
Signal Transduction In Response To DNA Damage
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Positive Regulation Of DNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
DNA Recombination
Nucleic Acid Metabolic Process
Regulation Of DNA Recombination
Nucleus
Regulation Of Double-strand Break Repair
Regulation Of Cell Cycle Phase Transition
Chromatin Remodeling
PML Body
Macromolecule Metabolic Process
Protein Modification Process
Chromatin Organization
Cellular Response To Radiation
Regulation Of Double-strand Break Repair Via Homologous Recombination
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of DNA Repair
Recombinational Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Site Of Double-strand Break
Regulation Of Primary Metabolic Process
Homologous Recombination
Ubiquitin-modified Histone Reader Activity
Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Process
Cellular Response To Ionizing Radiation
Positive Regulation Of DNA Recombination
Chromatin Organization
Nucleoplasm
Enzyme Binding
Chromatin Remodeling
Chromatin Binding
Regulation Of MiRNA Transcription
Protein Heterodimerization Activity
Regulation Of MiRNA Metabolic Process
Molecular Function Activator Activity
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Coactivator Binding
Developmental Growth
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Reproductive Process
Prostate Gland Growth
Nuclear Body
Mitotic DNA Damage Checkpoint Signaling
Protein-DNA Complex Assembly
Estrogen Response Element Binding
Mitotic DNA Integrity Checkpoint Signaling
Negative Regulation Of Biosynthetic Process
Chromosome
Positive Regulation Of Reproductive Process
Nucleus
Macromolecule Metabolic Process
Structural Constituent Of Chromatin
Protein-containing Complex
Cellular Response To Estrogen Stimulus
Mammary Gland Alveolus Development
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Core Promoter Sequence-specific DNA Binding
Nucleic Acid Metabolic Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Macromolecule Metabolic Process
Epigenetic Regulation Of Gene Expression
Nucleosome Assembly
DNA Binding
Regulation Of Cellular Response To Stress
Gene Expression
Prostate Gland Epithelium Morphogenesis
Estrogen Receptor Signaling Pathway
Nuclear Steroid Receptor Activity
Cellular Response To Oxygen-containing Compound
Protein-containing Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
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Tagcloud (Intersection)
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