COPS5 and RNF139

Number of citations of the paper that reports this interaction (PMID 12032852)
12

Data Source:
HPRD (in vitro)

		COPS5	RNF139
Gene Name		COP9 signalosome subunit 5	ring finger protein 139
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Protease Binding Ubiquitin-protein Transferase Activity Receptor Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-like Protein Transferase Activity
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Translation Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	6 interactors: COPS5 EIF3A UBE2H UBE2U UBE2Z VHL
Entrez ID		10987	11236
HPRD ID		06888	04333
Ensembl ID		ENSG00000121022
Uniprot IDs		Q92905	Q8WU17
PDB IDs		4F7O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Cellular Protein Modification Process Exosomal Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Mature Ribosome Assembly Cullin Deneddylation Ribosomal Subunit Export From Nucleus Cytoplasmic Translational Initiation Protein Deneddylation Cytoplasmic Translation Posttranscriptional Regulation Of Gene Expression Formation Of Translation Preinitiation Complex Protein K11-linked Ubiquitination Ribosomal Large Subunit Biogenesis Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Ribosome Assembly Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone Ubiquitination Protein Catabolic Process Protein K48-linked Ubiquitination Translation
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	11q 16p 16q 17p 17q 18q 19q 2q 3q 4q 6p 8p 8q 9p arrange casp1 cdkn2d cttn fgf3 il12b imbalances macroscopically mlpa mme mvp nfkb1 ptk2 ptp4a3 tusc3
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	11q 16p 16q 17p 17q 18q 19q 2q 3q 4q 6p 8p 8q 9p arrange casp1 cdkn2d cttn fgf3 il12b imbalances macroscopically mlpa mme mvp nfkb1 ptk2 ptp4a3 tusc3
Tagcloud (Intersection) ?