COPS5 and ERN1

Number of citations of the paper that reports this interaction (PubMedID 15234121)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		COPS5	ERN1
Description		COP9 signalosome subunit 5	endoplasmic reticulum to nucleus signaling 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation	Endothelial Cell Proliferation MRNA Processing RNA Catabolic Process MRNA Catabolic Process Protein Phosphorylation Apoptotic Process Response To Unfolded Protein Negative Regulation Of Gene Expression Regulation Of Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response Positive Regulation Of JNK Cascade MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)	IRE1alpha activates chaperones IRE1alpha activates chaperones
Drugs			N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib
Diseases
GWAS			Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver injury in anti-retroviral drug treated HIV ( 28388302)
Interacting Genes		113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG	15 interacting genes: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 P4HB PSEN1 RNF10 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2
Entrez ID		10987	2081
HPRD ID		06888	04943
Ensembl ID		ENSG00000121022	ENSG00000178607
Uniprot IDs		A0A024R7W9 Q92905	O75460
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC 6W39 6W3A 6W3B 6W3C 6W3E 6W3K 6XDB 6XDD 6XDF 7BMK 8UVL
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Stress Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein-folding Chaperone Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Intracellular Signal Transduction Protein Catabolic Process Regulation Of Signal Transduction BAK Complex B Cell Negative Selection Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein-containing Complex Assembly Cellular Response To Topologically Incorrect Protein Regulation Of Cell Communication Regulation Of Signaling Protein Modification Process Positive Regulation Of Protein Metabolic Process Post-embryonic Camera-type Eye Morphogenesis IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Intracellular Signaling Cassette Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Apoptotic Process Apoptotic Process Involved In Blood Vessel Morphogenesis Regulation Of JNK Cascade Cell Death Programmed Cell Death Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Protein Modification Process Post-embryonic Eye Morphogenesis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Chaperone-mediated Autophagy Tumor Necrosis Factor Binding
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