COPS5 and BCL2L14

Number of citations of the paper that reports this interaction (PubMedID 18006276)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)

		COPS5	BCL2L14
Description		COP9 signalosome subunit 5	BCL2 like 14
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Endomembrane System Membrane Intracellular Organelle
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity	Protein Binding Protein Kinase Binding
	Biological Process	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation	Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Phosphorus levels ( 29403010) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG	6 interacting genes: BCL2 BCL2L1 COPS5 DDIT4L PICK1 TEPSIN
Entrez ID		10987	79370
HPRD ID		06888	05841
Ensembl ID		ENSG00000121022	ENSG00000121380
Uniprot IDs		A0A024R7W9 Q92905	Q9BZR8
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex	Dendritic Cell Apoptotic Process BH3 Domain Binding Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Anoikis Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Regulation Of Anoikis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Epithelial Cell Apoptotic Process Ovarian Follicle Development Cellular Response To Glucose Starvation Leukocyte Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Leukocyte Apoptotic Process Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Apoptotic Process In Bone Marrow Cell Coated Vesicle Membrane Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Male Gonad Development Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Autophagy BAD-BCL-2 Complex Channel Inhibitor Activity Regulation Of Cellular Response To Stress Trans-Golgi Network Membrane Macrophage Migration Inhibitory Factor Binding Negative Regulation Of Signaling Mononuclear Cell Proliferation Negative Regulation Of Cell Communication Cochlear Nucleus Development Gonad Development Cellular Response To Decreased Oxygen Levels Regulation Of Nitrogen Utilization Leukocyte Proliferation
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