COPS5 and NR4A2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS5	NR4A2
Gene Name		COP9 signalosome subunit 5	nuclear receptor subfamily 4, group A, member 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Heterodimerization Activity
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Response To Hypoxia Neuron Migration Response To Amphetamine Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Adult Locomotory Behavior Post-embryonic Development Response To Inorganic Substance Gene Expression Death Response To Insecticide Central Nervous System Projection Neuron Axonogenesis Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Neuron Maturation Positive Regulation Of Catalytic Activity Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Transcription From RNA Polymerase II Promoter General Adaptation Syndrome Dopaminergic Neuron Differentiation
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Menarche (age at onset) ( 21102462) Response to statin therapy ( 20339536)
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	15 interactors: BAZ1B CDKN1C CDKN2D COPS5 PIAS4 PPARG RARA RARB RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 TCEAL5 VHL
Entrez ID		10987	4929
HPRD ID		06888	03493
Ensembl ID		ENSG00000121022	ENSG00000153234
Uniprot IDs		Q92905	F1D8N6 F5H4G9 P43354 Q53EL4 Q6NXU0
PDB IDs		4F7O	1OVL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Retinoic Acid RNA Biosynthetic Process Heart Development Transcription From RNA Polymerase II Promoter Cardiovascular System Development Hormone-mediated Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Muscle Cell Differentiation Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Proliferation Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Heart Morphogenesis DNA-templated Transcription, Initiation RNA Metabolic Process Muscle Structure Development Aortic Smooth Muscle Cell Differentiation Nitrogen Compound Metabolic Process Gene Expression
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	519d allograft artificial attenuate bac c19mc cxcl6 decidua evt evts extravillous feto foxl2 immunological indirectly invade microrna mirna mirnas myometrium naturally placenta placental trophoblast trophoblasts undifferentiated utr villous vts
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	519d allograft artificial attenuate bac c19mc cxcl6 decidua evt evts extravillous feto foxl2 immunological indirectly invade microrna mirna mirnas myometrium naturally placenta placental trophoblast trophoblasts undifferentiated utr villous vts
Tagcloud (Intersection) ?