COPS5 and HTR6

Number of citations of the paper that reports this interaction (PMID 20093369)
7

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		COPS5	HTR6
Gene Name		COP9 signalosome subunit 5	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Histamine Receptor Activity Serotonin Receptor Activity Protein Binding
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Serotonin Receptor Signaling Pathway Synaptic Transmission Learning Negative Regulation Of Glutamate Secretion Negative Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Negative Regulation Of Acetylcholine Secretion, Neurotransmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling Response To Estradiol Positive Regulation Of Dopamine Secretion Response To Drug Long-term Synaptic Potentiation
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs			Ziprasidone Olanzapine Clozapine Quetiapine Aripiprazole Dimethyltryptamine Iloperidone Sertindole Asenapine
Diseases
GWAS
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	4 interactors: COPS5 FYN GNAQ GNAS
Entrez ID		10987	3362
HPRD ID		06888	03066
Ensembl ID		ENSG00000121022	ENSG00000158748
Uniprot IDs		Q92905	P50406
PDB IDs		4F7O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Platelet Activation Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Regulation Of Protein Localization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Post-embryonic Body Morphogenesis Post-embryonic Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Embryonic Limb Morphogenesis Regulation Of Cellular Localization Limb Morphogenesis Regulation Of Protein Localization To Nucleus Limb Development Exosomal Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cognition Regulation Of Phosphorus Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Homotypic Cell-cell Adhesion Regulation Of Cell Differentiation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cullin Deneddylation Neuron Remodeling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Protein Deneddylation Regulation Of Gene Expression Response To Platelet-derived Growth Factor Forebrain Development Response To Peptide Hormone Regulation Of Melanocyte Differentiation Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Positive Regulation Of CAMP-mediated Signaling Response To Peptide Response To Drug Maternal Behavior Adrenergic Receptor Signaling Pathway Secretion By Cell Single Organismal Cell-cell Adhesion
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?