MDC1 and CHEK2

  • Number of citations of the paper that reports this interaction (PMID 12607004)
  • 76
  • Data Source:
  • HPRD (in vivo)

MDC1

CHEK2

Gene Name mediator of DNA-damage checkpoint 1 checkpoint kinase 2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251 47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL
Entrez ID 9656 11200
HPRD ID 16252 05084
Ensembl ID ENSG00000137337 ENSG00000183765
Uniprot IDs A1Z5I9 Q14676 O96017
PDB IDs 2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
53bp1  atm  break  breaks  cajal  delays  dsb  dsbs  facilitates  facilitating  h2ax  impairs  joining  localizes  neurodegeneration  nhej  nonhomologous  partner  premature  rad51  repair  rnf8  scaffold  strand  tcab1  ubiquitylation  wd40  wdr79  wrap53beta 
alleles  atm  brca1  brca2  brip1  cdh1  confer  contributing  contributive  fashion  hereditary  influences  lifetime  offers  otherwise  palb2  penetrance  penetrant  personal  polygenic  predisposing  predisposition  quite  snp  stk11  suggestive  suspicion  unlikely  venue 
Tagcloud (Difference) ?
53bp1  break  breaks  cajal  delays  dsb  dsbs  facilitates  facilitating  h2ax  impairs  joining  localizes  neurodegeneration  nhej  nonhomologous  partner  premature  rad51  repair  rnf8  scaffold  strand  tcab1  ubiquitylation  wd40  wdr79  wrap53beta 
alleles  brca1  brca2  brip1  cdh1  confer  contributing  contributive  fashion  hereditary  influences  lifetime  offers  otherwise  palb2  penetrance  penetrant  personal  polygenic  predisposing  predisposition  quite  snp  stk11  suggestive  suspicion  unlikely  venue 
Tagcloud (Intersection) ?
atm