COPS5 and BCL3

Number of citations of the paper that reports this interaction (PubMedID 10362352)
0

Data Source:
HPRD (in vivo)

		COPS5	BCL3
Description		COP9 signalosome subunit 5	BCL3 transcription coactivator
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Midbody Protein-containing Complex Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation	Negative Regulation Of Cytokine Production Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Protein Import Into Nucleus Apoptotic Process Response To Stress DNA Damage Response Canonical NF-kappaB Signal Transduction Response To Virus Response To UV-C Positive Regulation Of Gene Expression Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production T-helper 1 Type Immune Response Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Translation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Spleen Development Regulation Of DNA Binding Response To Other Organism T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS			Alzheimer's disease ( 24755620 30636644) Alzheimer's disease (late onset) ( 23565137) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Asthma ( 32296059) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG	35 interacting genes: AKT1 ANKRD28 BARD1 CHUK COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK1 MAPK3 MAPRE1 N4BP2 NCOA1 NFKB1 NFKB2 PIR RAB9A RUVBL2 RXRA SHC1 TBP TRAF6
Entrez ID		10987	602
HPRD ID		06888	00179
Ensembl ID		ENSG00000121022	ENSG00000069399
Uniprot IDs		A0A024R7W9 Q92905	B7Z3N9 P20749
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	1K1A 1K1B
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Response To Lipid Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Intracellular Signal Transduction Regulation Of Gene Expression Nucleoplasm RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Transcription By RNA Polymerase II Cytosol Enzyme Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Chromatin Binding Nucleus Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Tau Protein Binding Regulation Of Apoptotic Process Transcription Corepressor Binding Macromolecule Biosynthetic Process Macromolecule Metabolic Process
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