MDC1 and VAMP5

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		MDC1	VAMP5
Gene Name		mediator of DNA-damage checkpoint 1	vesicle-associated membrane protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion	Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Intercalated Disc Cytoplasmic Vesicle Membrane SNARE Complex Integral Component Of Organelle Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding FHA Domain Binding	SNARE Binding SNAP Receptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Intra-S DNA Damage Checkpoint	Exocytosis Vesicle Fusion Neurotransmitter Secretion Muscle Organ Development Skeletal Muscle Tissue Development Cell Differentiation Golgi To Plasma Membrane Protein Transport
Pathways		ATM mediated phosphorylation of repair proteins ATM mediated response to DNA double-strand break Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS			Prostate cancer ( 21743467)
Protein-Protein Interactions		37 interactors: ANAPC1 ATM BARD1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AFX HDAC10 HDAC8 HINFP LOC729324 NBN NCL PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SUMO1 SUMO2 TP53 TP53BP1 UIMC1 USP28 VAMP5 WHSC1 WRN ZNF251	6 interactors: MDC1 SNAP23 SNAP29 STX16 STX1A STX4
Entrez ID		9656	10791
HPRD ID		16252	09513
Ensembl ID		ENSG00000137337	ENSG00000168899
Uniprot IDs		A1Z5I9 Q14676	O95183 Q6FG93
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cell Cycle Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process Response To Ionizing Radiation Positive Regulation Of Metabolic Process Chromosome Organization Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Response To Radiation Regulation Of Metabolic Process DNA Recombination Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To Abiotic Stimulus Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Protein Modification Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Vesicle Fusion Synaptic Vesicle Fusion To Presynaptic Membrane Organelle Fusion Membrane Fusion Vesicle Organization Synaptic Vesicle Exocytosis Neurotransmitter Secretion Synaptic Vesicle Transport Regulation Of Neurotransmitter Levels Neurotransmitter Transport Establishment Of Vesicle Localization Vesicle Localization Membrane Organization Establishment Of Organelle Localization Exocytosis Vesicle Docking Membrane Docking Organelle Localization Synaptic Vesicle Priming Secretion By Cell Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Synaptic Transmission Secretion Protein Localization Establishment Of Localization In Cell Golgi Vesicle Transport Cell-cell Signaling Vesicle Targeting Cellular Protein Complex Assembly Cellular Localization Positive Regulation Of Exocytosis Post-Golgi Vesicle-mediated Transport Organelle Organization Intracellular Transport Positive Regulation Of Synaptic Transmission Cellular Macromolecular Complex Assembly Positive Regulation Of Eosinophil Degranulation Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Protein Complex Assembly Golgi Ribbon Formation Regulation Of Hormone Secretion Positive Regulation Of Protein Localization To Cell Surface Transport Autophagic Vacuole Fusion Positive Regulation Of Immunoglobulin Secretion
Tagcloud ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	apparatus arrangement autolysosomes caveolin compartments differentiating ends existence golgi junction myofibers myotendinous myotube myotubes near neuromuscular organelles perinuclear reticulum rough sarcolemma sarcoplasmic tubules vamp2 vamp3 vamps vesicle vesicles vesicular
Tagcloud (Difference) ?		53bp1 atm break breaks cajal delays dsb dsbs facilitates facilitating h2ax impairs joining localizes neurodegeneration nhej nonhomologous partner premature rad51 repair rnf8 scaffold strand tcab1 ubiquitylation wd40 wdr79 wrap53beta	apparatus arrangement autolysosomes caveolin compartments differentiating ends existence golgi junction myofibers myotendinous myotube myotubes near neuromuscular organelles perinuclear reticulum rough sarcolemma sarcoplasmic tubules vamp2 vamp3 vamps vesicle vesicles vesicular
Tagcloud (Intersection) ?