COPS5 and PLAC8

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		COPS5	PLAC8
Gene Name		COP9 signalosome subunit 5	placenta-specific 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Chromatin Binding
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Positive Regulation Of Cell Proliferation Response To Cold Negative Regulation Of Multicellular Organism Growth Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Brown Fat Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	3 interactors: COPS5 RBPMS TRIP13
Entrez ID		10987	51316
HPRD ID		06888	06335
Ensembl ID		ENSG00000121022	ENSG00000145287
Uniprot IDs		Q92905	Q9NZF1
PDB IDs		4F7O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Exosomal Secretion Transcription, DNA-templated Cullin Deneddylation RNA Biosynthetic Process Protein Deneddylation Female Meiosis I Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus RNA Metabolic Process Synaptonemal Complex Assembly Oocyte Maturation Synaptonemal Complex Organization Gene Expression Cellular Macromolecule Biosynthetic Process Male Meiosis I Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Female Meiotic Division Reciprocal Meiotic Recombination Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Oocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Synapsis Homologous Chromosome Segregation Nucleobase-containing Compound Metabolic Process Male Meiosis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Oogenesis Meiotic Chromosome Segregation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Import Into Nucleus Nitrogen Compound Metabolic Process Meiosis I Protein Deubiquitination Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Female Gamete Generation Protein Modification By Small Protein Removal Spermatid Development Cell Maturation Spermatid Differentiation
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	adenocarcinoma autophagic autophagosome autophagy blocking coexist compartment cooperate correspondingly ductal engineered facilitating inactivation link localizing lysosomal lysosome machinery maintaining mechanistic mediators oncogenic pancreatic pda potently ras reprogramming suppresses synergistically
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	adenocarcinoma autophagic autophagosome autophagy blocking coexist compartment cooperate correspondingly ductal engineered facilitating inactivation link localizing lysosomal lysosome machinery maintaining mechanistic mediators oncogenic pancreatic pda potently ras reprogramming suppresses synergistically
Tagcloud (Intersection) ?