MDC1 and HDAC10

Number of citations of the paper that reports this interaction (PubMedID 14578343)
0

Data Source:
BioGRID (unspecified method)

		MDC1	HDAC10
Description		mediator of DNA damage checkpoint 1	histone deacetylase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body Site Of Double-strand Break	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Chromatin-protein Adaptor Activity Histone Reader Activity	Histone Deacetylase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Deacetylase Activity Enzyme Binding Protein Lysine Deacetylase Activity Histone Deacetylase Binding Metal Ion Binding Acetylputrescine Deacetylase Activity Acetylspermidine Deacetylase Activity
	Biological Process	DNA Replication Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Protein K6-linked Ubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Recombination Chromatin Organization Regulation Of DNA-templated Transcription Autophagy DNA Damage Response Macroautophagy Positive Regulation Of Mismatch Repair Homologous Recombination Negative Regulation Of DNA-templated Transcription Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs			Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Eosinophil count ( 31272903)	Acne (severe) ( 24927181) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		42 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 USP7 VAMP5 WRN ZNF251	9 interacting genes: HDAC2 HDAC3 HSPA8 MDC1 MTNR1A NCOR2 PAX3 TRIM28 TRIM54
Entrez ID		9656	83933
HPRD ID		16252	09407
Ensembl ID		ENSG00000137337	ENSG00000100429
Uniprot IDs		A0A1U9XBC1 A0A1U9XBE3 A0A1U9XBF2 A1Z5I9 Q14676	Q969S8
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT 9IF9
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of DNA Repair Response To Ionizing Radiation Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress DNA Damage Checkpoint Signaling Post-translational Protein Modification Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Nucleic Acid Metabolic Process Regulation Of DNA Recombination Nucleus Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Phase Transition Chromatin Remodeling PML Body Macromolecule Metabolic Process Protein Modification Process Chromatin Organization Cellular Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Macromolecule Metabolic Process Response To Stress Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Recombinational Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Regulation Of Primary Metabolic Process Homologous Recombination Ubiquitin-modified Histone Reader Activity Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation Positive Regulation Of DNA Recombination	Protein De-2-hydroxyisobutyrylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Rhythmic Process Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Histone Deacetylase Binding Heterochromatin Formation Circadian Rhythm Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin NF-kappaB Binding Transcription Corepressor Activity Positive Regulation Of Protein Import Into Nucleus Histone Deacetylase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Heat Shock Protein Binding Response To Lipid Chaperone-mediated Autophagy Translocation Complex Disassembly Transcription Repressor Complex Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Ferroptosis Cellular Response To Stress Chromatin Organization Promoter-specific Chromatin Binding Nucleoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Transcription By RNA Polymerase II Lumenal Side Of Lysosomal Membrane Krueppel-associated Box Domain Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Transport Regulation Of Interleukin-1 Production Fungiform Papilla Formation Regulation Of Protein Import Ubiquitin-like Protein Ligase Activity
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