COPS5 and NR4A3

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS5	NR4A3
Gene Name		COP9 signalosome subunit 5	nuclear receptor subfamily 4, group A, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Mesoderm Formation Transcription Initiation From RNA Polymerase II Promoter Axon Guidance Biological_process Gene Expression Hippocampus Development Intracellular Receptor Signaling Pathway Adult Behavior Organ Regeneration Response To Hydrogen Peroxide Steroid Hormone Mediated Signaling Pathway Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Semicircular Canal Morphogenesis Neuromuscular Process Controlling Balance Vestibular Reflex Positive Regulation Of Leukocyte Apoptotic Process
Pathways
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	5 interactors: COPS5 RPS6KA1 SIX3 TRIM28 VHL
Entrez ID		10987	8013
HPRD ID		06888	02766
Ensembl ID		ENSG00000121022	ENSG00000119508
Uniprot IDs		Q92905	Q92570
PDB IDs		4F7O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Neuroblast Migration Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA Demethylation Optic Vesicle Morphogenesis Positive Regulation Of Hepatic Stellate Cell Activation Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Regulation Of Neural Retina Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Lens Fiber Cell Apoptotic Process Neuroblast Differentiation Exosomal Secretion Cell Morphogenesis Negative Regulation Of Transcription, DNA-templated Proximal/distal Axis Specification Convergent Extension Involved In Axis Elongation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Negative Regulation Of Gene Expression Stem Cell Differentiation Negative Regulation Of Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Cullin Deneddylation Forebrain Dorsal/ventral Pattern Formation Lens Induction In Camera-type Eye Protein Deneddylation Cellular Response To Stress Regulation Of Cell Differentiation Convergent Extension Telencephalon Regionalization Negative Regulation Of Viral Release From Host Cell Regulation Of Metabolic Process
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	annotation ccaat cebpd crosstalk cytoscape degs dissect downloaded encyclopedia fbj fosb gse14245 gse21654 gse32676 hub klf5 kruppel kyoto logarithm logfc omnibus ontology pentraxin ppi ptx3 sfn stratifin tfs trasfac
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	annotation ccaat cebpd crosstalk cytoscape degs dissect downloaded encyclopedia fbj fosb gse14245 gse21654 gse32676 hub klf5 kruppel kyoto logarithm logfc omnibus ontology pentraxin ppi ptx3 sfn stratifin tfs trasfac
Tagcloud (Intersection) ?